Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration
sources used in biological dosimetry was achieved to investigate the influence of calibration practices
and protocols on the results of the dose estimation performance as a first step to harmonization and
standardization of dosimetry and irradiation practices in the European biological dosimetry network.
Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined
with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood
samples. A short survey was also performed to collect the information needed for the data analysis
and evaluate the diversity of practices.
Results: For most of partners the deviation of delivered dose from the targeted dose remains below
10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies
were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some
ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation
(PCC) assays has been performed leading to an improvement of the overall performances.
Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs
of harmonization, standardization in irradiation and dosimetry practices and educational training for
biologists using ionizing radiation.