Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects

Hanane Derradji, Sofie Bekaert, Tim De Meyer, Paul Jacquet, Khalil Abouelaradat, Myriam Ghardi, Arlette Michaux, Sarah Baatout

    Research outputpeer-review


    In this paper, the cellular and molecular mechanisms underlying radiation-induced forelimb defects were studied. Our data suggest that transcriptional modulations of apoptotic, inflammation, stress, and DNA damage players are early events in radiation-induced forelimb defects. These changes resulted in harsh developmental conditions as indicated by a marked increase in cytokine levels in the amniotic fluid and telomere shortening, two features concomitant with the onset of the forelimb defect phenotype in our study.
    Original languageEnglish
    Pages (from-to)302-313
    JournalDevelopmental Biology
    Issue number2
    StatePublished - Oct 2008

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