Lack of mutagenic activity of white spirit

B. Gochet; C. de Meester; A. Léonard; Gh Deknudt

doi:10.1007/BF00380675

Lack of mutagenic activity of white spirit

B. Gochet, C. de Meester, A. Léonard, Gh Deknudt

Research output › peer-review

Abstract

The mutagenic potential of white spirit, a typical mixture of primarily aliphatic hydrocarbons used as a solvent, was investigated using a battery of test systems. The ability of this compound to induce gene mutations was assayed by the Ames' test with different strains of Salmonella typhimurium; its potential clastogenicity was tested in vivo on mouse bone marrow cells; in-vitro induction of sister chromatid exchanges was studied in human lymphocytes. Negative results were obtained in all test systems. It is concluded that, in spite of its evident toxicity, white spirit does not display mutagenic properties.

Original language	English
Pages (from-to)	359-364
Number of pages	6
Journal	International Archives of Occupational and Environmental Health
Volume	53
Issue number	4
DOIs	https://doi.org/10.1007/BF00380675
State	Published - Mar 1984

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Access to Document

10.1007/BF00380675

Cite this

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title = "Lack of mutagenic activity of white spirit",

abstract = "The mutagenic potential of white spirit, a typical mixture of primarily aliphatic hydrocarbons used as a solvent, was investigated using a battery of test systems. The ability of this compound to induce gene mutations was assayed by the Ames' test with different strains of Salmonella typhimurium; its potential clastogenicity was tested in vivo on mouse bone marrow cells; in-vitro induction of sister chromatid exchanges was studied in human lymphocytes. Negative results were obtained in all test systems. It is concluded that, in spite of its evident toxicity, white spirit does not display mutagenic properties.",

keywords = "Mutagenicity, White spirit",

author = "B. Gochet and {de Meester}, C. and A. L{\'e}onard and Gh Deknudt",

year = "1984",

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pages = "359--364",

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T1 - Lack of mutagenic activity of white spirit

AU - Gochet, B.

AU - de Meester, C.

AU - Léonard, A.

AU - Deknudt, Gh

PY - 1984/3

Y1 - 1984/3

N2 - The mutagenic potential of white spirit, a typical mixture of primarily aliphatic hydrocarbons used as a solvent, was investigated using a battery of test systems. The ability of this compound to induce gene mutations was assayed by the Ames' test with different strains of Salmonella typhimurium; its potential clastogenicity was tested in vivo on mouse bone marrow cells; in-vitro induction of sister chromatid exchanges was studied in human lymphocytes. Negative results were obtained in all test systems. It is concluded that, in spite of its evident toxicity, white spirit does not display mutagenic properties.

AB - The mutagenic potential of white spirit, a typical mixture of primarily aliphatic hydrocarbons used as a solvent, was investigated using a battery of test systems. The ability of this compound to induce gene mutations was assayed by the Ames' test with different strains of Salmonella typhimurium; its potential clastogenicity was tested in vivo on mouse bone marrow cells; in-vitro induction of sister chromatid exchanges was studied in human lymphocytes. Negative results were obtained in all test systems. It is concluded that, in spite of its evident toxicity, white spirit does not display mutagenic properties.

KW - Mutagenicity

KW - White spirit

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