TY - JOUR
T1 - Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests
AU - Léonard, A.
AU - de Meester, C.
AU - Fabry, L.
AU - de Saint-Georges, L.
AU - Dumont, P.
PY - 1984
Y1 - 1984
N2 - The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.
AB - The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.
UR - http://www.scopus.com/inward/record.url?scp=0021159414&partnerID=8YFLogxK
U2 - 10.1016/0165-1218(84)90095-8
DO - 10.1016/0165-1218(84)90095-8
M3 - Article
C2 - 6433192
AN - SCOPUS:0021159414
SN - 0165-1218
VL - 137
SP - 79
EP - 88
JO - Mutation Research/Genetic Toxicology
JF - Mutation Research/Genetic Toxicology
IS - 2-3
ER -