Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests

A. Léonard; C. de Meester; L. Fabry; L. de Saint-Georges; P. Dumont

doi:10.1016/0165-1218(84)90095-8

Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests

A. Léonard
, C. de Meester
, L. Fabry
, L. de Saint-Georges
, P. Dumont

Research output › peer-review

Abstract

The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.

Original language	English
Pages (from-to)	79-88
Number of pages	10
Journal	Mutation Research/Genetic Toxicology
Volume	137
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-1218(84)90095-8
State	Published - 1984

ASJC Scopus subject areas

Toxicology
Genetics

Access to Document

10.1016/0165-1218(84)90095-8

Cite this

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title = "Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests",

abstract = "The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.",

author = "A. L{\'e}onard and \{de Meester\}, C. and L. Fabry and \{de Saint-Georges\}, L. and P. Dumont",

year = "1984",

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journal = "Mutation Research/Genetic Toxicology",

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T1 - Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests

AU - Léonard, A.

AU - de Meester, C.

AU - Fabry, L.

AU - de Saint-Georges, L.

AU - Dumont, P.

PY - 1984

Y1 - 1984

N2 - The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.

AB - The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.

UR - https://www.scopus.com/pages/publications/0021159414

U2 - 10.1016/0165-1218(84)90095-8

DO - 10.1016/0165-1218(84)90095-8

M3 - Article

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AN - SCOPUS:0021159414

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VL - 137

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JO - Mutation Research/Genetic Toxicology

JF - Mutation Research/Genetic Toxicology

IS - 2-3

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