Le cycle cellulaire chez les mammifères

All eukaryotic cells possess similar mechanisms to regulate the progression of the cell cycle. Cyclins and cyclin-dependent kinases are the key molecules implicated in the cell cycle and their activities are extremely regulated. Recently, cyclin-dependent kinase inhibitors have been characterized. Their function allows us to better understand the cell cycle machinery. In this review, we will attempt to explain the mode of action of cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors and their implications in cancer.