Localisation intracellulaire, dans le foie de rat, d'un facteur inhibiteur de la synthése de l'acide désoxyribonucléique in vitro

R. Goutier; I. Bologna

doi:10.1016/0926-6550(63)90307-4

Localisation intracellulaire, dans le foie de rat, d'un facteur inhibiteur de la synthése de l'acide désoxyribonucléique in vitro

R. Goutier, I. Bologna

Research output › peer-review

Abstract

We measured the in vitro synthesis of DNA in the presence of aqueous extracts of regenerating rat livers. Suspensions of microsomes from normal liver powerfully inhibit this incorporation. The observed inhibition is not due to a hydrolysis of primer DNA by alkaline DNAase (EC 3.1.4.5) nor to a dephosphorylation of the precursors by phosphatases. Microsomes prepared from regenerating livers have a smaller inhibitory power than that of normal liver microsomes.

Original language	English
Pages (from-to)	40-47
Number of pages	8
Journal	Biochimica et biophysica acta; Nucleic acids and protein synthesis
Volume	72
Issue number	C
DOIs	https://doi.org/10.1016/0926-6550(63)90307-4
State	Published - 1963
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/0926-6550(63)90307-4

Cite this

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abstract = "We measured the in vitro synthesis of DNA in the presence of aqueous extracts of regenerating rat livers. Suspensions of microsomes from normal liver powerfully inhibit this incorporation. The observed inhibition is not due to a hydrolysis of primer DNA by alkaline DNAase (EC 3.1.4.5) nor to a dephosphorylation of the precursors by phosphatases. Microsomes prepared from regenerating livers have a smaller inhibitory power than that of normal liver microsomes.",

author = "R. Goutier and I. Bologna",

year = "1963",

doi = "10.1016/0926-6550(63)90307-4",

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N2 - We measured the in vitro synthesis of DNA in the presence of aqueous extracts of regenerating rat livers. Suspensions of microsomes from normal liver powerfully inhibit this incorporation. The observed inhibition is not due to a hydrolysis of primer DNA by alkaline DNAase (EC 3.1.4.5) nor to a dephosphorylation of the precursors by phosphatases. Microsomes prepared from regenerating livers have a smaller inhibitory power than that of normal liver microsomes.

AB - We measured the in vitro synthesis of DNA in the presence of aqueous extracts of regenerating rat livers. Suspensions of microsomes from normal liver powerfully inhibit this incorporation. The observed inhibition is not due to a hydrolysis of primer DNA by alkaline DNAase (EC 3.1.4.5) nor to a dephosphorylation of the precursors by phosphatases. Microsomes prepared from regenerating livers have a smaller inhibitory power than that of normal liver microsomes.

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