Low temperature radiolabelling of human serum albumin constructs with terbium-161 and ex vivo biodistribution to assess in vivo stability

Irwin Cassells, Maarten Ooms, Andrew Burgoyne, Jozef Cornelis, Stephen Ahenkorah, Michiel Van de Voorde, Thomas Cardinaels, Christophe Deroose, Guy Bormans, Frederik Cleeren

    Research outputpeer-review


    Targeted radionuclide therapy using Terbium-161 (161Tb) is a promising approach for β- and Auger electron therapy. Heat-sensitive biomolecules (e.g. nanobodies) are increasingly being used as carriers in radiometal-based pharmaceuticals, however current radiolabelling techniques require heating (>85 °C) incompatible with heat-sensitive carrier molecules. In this study, we evaluated bifunctional chelators that allow 61Tblabelling under mild conditions using human serum albumin (HSA) and assessed the in vivo stability of the constructs.
    Original languageEnglish
    Title of host publicationEuropean Journal of Nuclear Medicine and Molecular Imaging
    Number of pages1
    StatePublished - 30 Oct 2020
    Event2020 - EANM: European Association of Nuclear Medicine - Online
    Duration: 22 Oct 202030 Oct 2020

    Publication series

    NameEuropean Journal of Nuclear Medicine and Molecular Imaging
    NumberSupplement 1
    ISSN (Print)1619-7070


    Conference2020 - EANM
    Internet address

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