Abstract
Targeted radionuclide therapy using Terbium-161 (161Tb) is a promising approach for β- and Auger electron therapy. Heat-sensitive biomolecules (e.g. nanobodies) are increasingly being used as carriers in radiometal-based pharmaceuticals, however current radiolabelling techniques require heating (>85 °C) incompatible with heat-sensitive carrier molecules. In this study, we evaluated bifunctional chelators that allow 61Tblabelling
under mild conditions using human serum albumin (HSA) and assessed the in vivo stability of the constructs.
Original language | English |
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Title of host publication | European Journal of Nuclear Medicine and Molecular Imaging |
Pages | S753 |
Number of pages | 1 |
DOIs | |
State | Published - 30 Oct 2020 |
Event | 2020 - EANM: European Association of Nuclear Medicine - Online Duration: 22 Oct 2020 → 30 Oct 2020 https://eanm20.eanm.org/ |
Publication series
Name | European Journal of Nuclear Medicine and Molecular Imaging |
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Publisher | Springer |
Number | Supplement 1 |
Volume | 47 |
ISSN (Print) | 1619-7070 |
Conference
Conference | 2020 - EANM |
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Period | 2020-10-22 → 2020-10-30 |
Internet address |