Mécanismes de l'apoptose radio-induite

Sarah Baatout; Hanane Derradji; Olivier Petitfour; Hanna Von Suchodoletz; Max Mergeay

doi:10.1139/y02-097

Mécanismes de l'apoptose radio-induite

Sarah Baatout, Hanane Derradji, Olivier Petitfour, Hanna Von Suchodoletz, Max Mergeay

Research output › peer-review

Abstract

A general overview of the activation mechanisms of programmed cell death or apoptosis following an irradiation is given in this review. First, are summarized the main induction pathways of radiation-induced apoptosis by which extracellular (tumor necrosis factor (TNF), Fas ligand, TNF-related apoptosis-inducing ligand (TRAIL)) and intracellular (mitochondria and caspases) signals are integrated. A second part is then devoted to the importance of p53 and of its regulators (ATR, ATM, DNA-PKcs) in the process of radiation-induced apoptosis. Thereafter, signal transduction pathways and more specially the role of some protein kinases (MEKK, SAPK/JNK, p38-MAPK) is treated. At last, a chapter concerns the clinical interest of radiation-induced apoptosis and the implication of apoptosis in the treatment of certain diseases.

Translated title of the contribution	Mechanisms of radiation-induced apoptosis
Original language	French
Pages (from-to)	629-637
Number of pages	9
Journal	Canadian Journal of Physiology and Pharmacology
Volume	80
Issue number	7
DOIs	https://doi.org/10.1139/y02-097
State	Published - Jul 2002

ASJC Scopus subject areas

Physiology
Pharmacology
Physiology (medical)

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Cite this

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title = "M{\'e}canismes de l'apoptose radio-induite",

abstract = "A general overview of the activation mechanisms of programmed cell death or apoptosis following an irradiation is given in this review. First, are summarized the main induction pathways of radiation-induced apoptosis by which extracellular (tumor necrosis factor (TNF), Fas ligand, TNF-related apoptosis-inducing ligand (TRAIL)) and intracellular (mitochondria and caspases) signals are integrated. A second part is then devoted to the importance of p53 and of its regulators (ATR, ATM, DNA-PKcs) in the process of radiation-induced apoptosis. Thereafter, signal transduction pathways and more specially the role of some protein kinases (MEKK, SAPK/JNK, p38-MAPK) is treated. At last, a chapter concerns the clinical interest of radiation-induced apoptosis and the implication of apoptosis in the treatment of certain diseases.",

keywords = "Apoptosis, Caspase, Mitochondria, p53, Radiation",

author = "Sarah Baatout and Hanane Derradji and Olivier Petitfour and {Von Suchodoletz}, Hanna and Max Mergeay",

year = "2002",

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doi = "10.1139/y02-097",

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T1 - Mécanismes de l'apoptose radio-induite

AU - Baatout, Sarah

AU - Derradji, Hanane

AU - Petitfour, Olivier

AU - Von Suchodoletz, Hanna

AU - Mergeay, Max

PY - 2002/7

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AB - A general overview of the activation mechanisms of programmed cell death or apoptosis following an irradiation is given in this review. First, are summarized the main induction pathways of radiation-induced apoptosis by which extracellular (tumor necrosis factor (TNF), Fas ligand, TNF-related apoptosis-inducing ligand (TRAIL)) and intracellular (mitochondria and caspases) signals are integrated. A second part is then devoted to the importance of p53 and of its regulators (ATR, ATM, DNA-PKcs) in the process of radiation-induced apoptosis. Thereafter, signal transduction pathways and more specially the role of some protein kinases (MEKK, SAPK/JNK, p38-MAPK) is treated. At last, a chapter concerns the clinical interest of radiation-induced apoptosis and the implication of apoptosis in the treatment of certain diseases.

KW - Apoptosis

KW - Caspase

KW - Mitochondria

KW - p53

KW - Radiation

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