MADOR: a new tool to calculate decrease of effective doses in human after DTPA therapy

P. Fritsch; O. O. Grémy; Christian Hurtgen; P. Bérard; L. Grappin; J.L. Poncy; Freddy Verrezen

doi:10.1093/rpd/ncq429

MADOR: a new tool to calculate decrease of effective doses in human after DTPA therapy

P. Fritsch, O. O. Grémy, Christian Hurtgen, P. Bérard, L. Grappin, J.L. Poncy, Freddy Verrezen

Research output › peer-review

Abstract

Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide–DTPA complexes. After coupling these models with those currently used for dose calculation, the modelling approach was assessed by fitting human data available in IDEAS database. Good fits were obtained for most studied cases, but further experimental studies are needed to validate some modelling hypotheses as well as the range of parameter values. From these first results, radioprotection tools are being developed: MAnagement of DOse Reduction after DTPA therapy.

Original language	English
Pages (from-to)	371-375
Journal	Radiation protection dosimetry
Volume	144
Issue number	1-4
DOIs	https://doi.org/10.1093/rpd/ncq429
State	Published - 1 Mar 2011

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Cite this

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abstract = "Abstract models have been developed to describe dissolution of Pu/Am/Cm after internal contamination by inhalation or wound, chelation of actinides by diethylene triamine penta acetic acid (DTPA) in different retention compartments and excretion of actinide–DTPA complexes. After coupling these models with those currently used for dose calculation, the modelling approach was assessed by fitting human data available in IDEAS database. Good fits were obtained for most studied cases, but further experimental studies are needed to validate some modelling hypotheses as well as the range of parameter values. From these first results, radioprotection tools are being developed: MAnagement of DOse Reduction after DTPA therapy.",

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