Metabolism of 5-hydroxytryptophan in isolated perfused liver from normal and x-irradiated rats

G. B. Gerber; J. Deroo

doi:10.1007/BF01194256

Metabolism of 5-hydroxytryptophan in isolated perfused liver from normal and x-irradiated rats

G. B. Gerber, J. Deroo

Research output › peer-review

Abstract

Metabolism of¹⁴C-5-OH-tryptophan was studied in isolated perfused liver from normal and whole body irradiated rats (7 to 8 days after 1000 R). Metabolism of 5-OH-tryptophan is slow compared to that of 5-OH-tryptamine, and the metabolites isolated were mainly conjugates of 5-OH-tryptamine and 5-OH-indole acetic acid. Irradiation does not diminish significantly the conversion of 5-OH-tryptophan to 5-OH-tryptamine, rather an increased formation of 5-OH-indole acetic acid and of conjugates could be observed in irradiated liver.

Original language	English
Pages (from-to)	9-18
Number of pages	10
Journal	Biophysik
Volume	8
Issue number	1
DOIs	https://doi.org/10.1007/BF01194256
State	Published - Mar 1971

ASJC Scopus subject areas

Radiation
Biophysics
Environmental Chemistry
Radiology Nuclear Medicine and imaging
Environmental Science (miscellaneous)
General Environmental Science
Agricultural and Biological Sciences (miscellaneous)
Physics and Astronomy (miscellaneous)

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10.1007/BF01194256

Cite this

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title = "Metabolism of 5-hydroxytryptophan in isolated perfused liver from normal and x-irradiated rats",

abstract = "Metabolism of14C-5-OH-tryptophan was studied in isolated perfused liver from normal and whole body irradiated rats (7 to 8 days after 1000 R). Metabolism of 5-OH-tryptophan is slow compared to that of 5-OH-tryptamine, and the metabolites isolated were mainly conjugates of 5-OH-tryptamine and 5-OH-indole acetic acid. Irradiation does not diminish significantly the conversion of 5-OH-tryptophan to 5-OH-tryptamine, rather an increased formation of 5-OH-indole acetic acid and of conjugates could be observed in irradiated liver.",

author = "Gerber, {G. B.} and J. Deroo",

year = "1971",

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