Mitochondria: a matter of life and death after irradiation?

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    Abstract

    Recent epidemiological studies suggest ionizing radiation exposure as a risk factor of atherosclerosis. The key targets in radiation-induced cardiovascular damage are considered to be the endothelial cells, lining the cardiovascular system. To date, the mechanisms that clarify the endothelial cell response towards ionizing radiation are not fully identified. In general, it is known that atherosclerosis is characterized by oxidative stress leading to DNA damage, inflammation, cell senescence and cell death. We hypothesized that mitochondria drive the radiosensitivity of endothelial cells due to increased production of reactive oxygen species (ROS) after X-ray exposure, resulting in a higher risk of DNA damage.
    Original languageEnglish
    QualificationMaster of Science
    Awarding Institution
    • Uhasselt - Hasselt University
    Supervisors/Advisors
    • Aerts, An, SCK CEN Mentor
    • Swennen, Quirine, Supervisor, External person
    Date of Award8 Jun 2016
    StatePublished - 8 Jun 2016

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