We review the current status of the European fusion materials modelling programme. We describe recent findings and outline potential areas for future development. Large-scale Density Functional Theory (DFT) calculations reveal the structure of the point defects in -Fe, and highlight the crucial part played by magnetism. The calculations give accurate migration energies of point defects and the strength of their interaction with He atoms. Kinetic models based on DFT results reproduce the stages of radiation damage recovery in iron, and stages of He–desorption from pre-implanted iron. Experiments aimed at validating the models will be carried out in the future using a multi-beam ion irradiation facility chosen for its versatility and rapid feedback.