Mutagenicity of N-nitrosodiethanolamine and its acetyl derivatives

P. Gilbert; L. Fabry; B. Rollmann; P. Lombart; J. Rondelet; F. Poncelet; A. Leonard; M. Mercier

doi:10.1016/0165-1218(81)90240-8

Mutagenicity of N-nitrosodiethanolamine and its acetyl derivatives

P. Gilbert, L. Fabry, B. Rollmann, P. Lombart, J. Rondelet, F. Poncelet, A. Leonard, M. Mercier

Research output › peer-review

Abstract

The mutagenicity of N-nitrosodiethanolamine and its mono- and di-acetyl derivatives was tested in the S. typhimurium test system, in cytogenetic studies and in the micronucleus test. N-Nitrosodiethanolamine had no mutagenic effects towards several strains of S. typhimurium either in the absence or in the presence of metabolic activating systems. Its diacetyl derivative exerted mutagenic effects towards the S. typhimurium strains TA1530 and TA100. Neither compound increased significantly the number of chromosomal aberrations or of micronuclei in mice.

Original language	English
Pages (from-to)	217-224,226-228
Journal	Mutation Research/Genetic Toxicology
Volume	89
Issue number	3
DOIs	https://doi.org/10.1016/0165-1218(81)90240-8
State	Published - Jul 1981

ASJC Scopus subject areas

Toxicology
Genetics

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10.1016/0165-1218(81)90240-8

Cite this

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title = "Mutagenicity of N-nitrosodiethanolamine and its acetyl derivatives",

abstract = "The mutagenicity of N-nitrosodiethanolamine and its mono- and di-acetyl derivatives was tested in the S. typhimurium test system, in cytogenetic studies and in the micronucleus test. N-Nitrosodiethanolamine had no mutagenic effects towards several strains of S. typhimurium either in the absence or in the presence of metabolic activating systems. Its diacetyl derivative exerted mutagenic effects towards the S. typhimurium strains TA1530 and TA100. Neither compound increased significantly the number of chromosomal aberrations or of micronuclei in mice.",

author = "P. Gilbert and L. Fabry and B. Rollmann and P. Lombart and J. Rondelet and F. Poncelet and A. Leonard and M. Mercier",

year = "1981",

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T1 - Mutagenicity of N-nitrosodiethanolamine and its acetyl derivatives

AU - Gilbert, P.

AU - Fabry, L.

AU - Rollmann, B.

AU - Lombart, P.

AU - Rondelet, J.

AU - Poncelet, F.

AU - Leonard, A.

AU - Mercier, M.

PY - 1981/7

Y1 - 1981/7

N2 - The mutagenicity of N-nitrosodiethanolamine and its mono- and di-acetyl derivatives was tested in the S. typhimurium test system, in cytogenetic studies and in the micronucleus test. N-Nitrosodiethanolamine had no mutagenic effects towards several strains of S. typhimurium either in the absence or in the presence of metabolic activating systems. Its diacetyl derivative exerted mutagenic effects towards the S. typhimurium strains TA1530 and TA100. Neither compound increased significantly the number of chromosomal aberrations or of micronuclei in mice.

AB - The mutagenicity of N-nitrosodiethanolamine and its mono- and di-acetyl derivatives was tested in the S. typhimurium test system, in cytogenetic studies and in the micronucleus test. N-Nitrosodiethanolamine had no mutagenic effects towards several strains of S. typhimurium either in the absence or in the presence of metabolic activating systems. Its diacetyl derivative exerted mutagenic effects towards the S. typhimurium strains TA1530 and TA100. Neither compound increased significantly the number of chromosomal aberrations or of micronuclei in mice.

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JO - Mutation Research/Genetic Toxicology

JF - Mutation Research/Genetic Toxicology

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