Mutagenicity tests with astemizole in vitro and in vivo

Ph Vanparys; L. Fabry; A. Léonard; R. Marsboom

doi:10.1007/BF00373399

Mutagenicity tests with astemizole in vitro and in vivo

Ph Vanparys, L. Fabry, A. Léonard, R. Marsboom

Research output › peer-review

Abstract

Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that it can be concluded that astemizole has no potential to induce chromosomal aberrations.

Original language	English
Pages (from-to)	167-173
Number of pages	7
Journal	Archives of Toxicology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1007/BF00373399
State	Published - Jul 1982

ASJC Scopus subject areas

Toxicology
Health, Toxicology and Mutagenesis

Access to Document

10.1007/BF00373399

Cite this

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title = "Mutagenicity tests with astemizole in vitro and in vivo",

abstract = "Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that it can be concluded that astemizole has no potential to induce chromosomal aberrations.",

keywords = "Aflatoxin B, Astemizole, Cyclophosphamide, Dominant lethal test, Metaphase analysis test, Micronucleus test, Mutagenicity testing, Sister chromatid exchanges test",

author = "Ph Vanparys and L. Fabry and A. L{\'e}onard and R. Marsboom",

year = "1982",

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pages = "167--173",

journal = "Archives of Toxicology",

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T1 - Mutagenicity tests with astemizole in vitro and in vivo

AU - Vanparys, Ph

AU - Fabry, L.

AU - Léonard, A.

AU - Marsboom, R.

PY - 1982/7

Y1 - 1982/7

N2 - Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that it can be concluded that astemizole has no potential to induce chromosomal aberrations.

AB - Possible induction of chromosomal aberrations and/or sister chromatid exchanges by astemizole was studied in vitro on human lymphocytes. In vivo chromosomal damage was assessed by a micronucleus test on rats and a dominant lethal test on both male and female mice. All these tests yielded negative results for astemizole so that it can be concluded that astemizole has no potential to induce chromosomal aberrations.

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KW - Astemizole

KW - Cyclophosphamide

KW - Dominant lethal test

KW - Metaphase analysis test

KW - Micronucleus test

KW - Mutagenicity testing

KW - Sister chromatid exchanges test

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