Mutagenicity tests with domperidone in vitro and in vivo

Ph Vanparys; L. Fabry; A. Leonard; R. Marsboom

doi:10.1016/0378-4274(82)90188-6

Mutagenicity tests with domperidone in vitro and in vivo

Ph Vanparys, L. Fabry, A. Leonard, R. Marsboom

Research output › peer-review

Abstract

Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes. All these tests produced negative findings and it is concluded that domperidone has no potential to induce chromosomal aberrations.

Original language	English
Pages (from-to)	215-222
Number of pages	8
Journal	Toxicology Letters
Volume	12
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-4274(82)90188-6
State	Published - Jul 1982

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(82)90188-6

Cite this

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title = "Mutagenicity tests with domperidone in vitro and in vivo",

abstract = "Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes. All these tests produced negative findings and it is concluded that domperidone has no potential to induce chromosomal aberrations.",

author = "Ph Vanparys and L. Fabry and A. Leonard and R. Marsboom",

year = "1982",

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AU - Vanparys, Ph

AU - Fabry, L.

AU - Leonard, A.

AU - Marsboom, R.

PY - 1982/7

Y1 - 1982/7

N2 - Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes. All these tests produced negative findings and it is concluded that domperidone has no potential to induce chromosomal aberrations.

AB - Possible induction of chromosomal aberrations by domperidone was studied in vivo by a micronucleus test on mice and a dominant lethal test on both male and female mice. In vitro chromosomal damage was assessed on short-term cultures of human lymphocytes. All these tests produced negative findings and it is concluded that domperidone has no potential to induce chromosomal aberrations.

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