Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

Eric B. Emanuelsson; Bjorn Baselet; Mieke Neefs; Sarah Baatout; Brit Proesmans; Lisa Daenen; Carl Johan Sundberg; Helene Rundqvist; Rodrigo Fernandez-Gonzalo

doi:10.1038/s41526-023-00289-w

Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

Eric B. Emanuelsson, Bjorn Baselet, Mieke Neefs, Sarah Baatout, Brit Proesmans, Lisa Daenen, Carl Johan Sundberg, Helene Rundqvist, Rodrigo Fernandez-Gonzalo

Research output › peer-review

Abstract

The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.

Original language	English
Article number	40
Number of pages	4
Journal	npj Microgravity
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41526-023-00289-w
State	Published - Dec 2023

ASJC Scopus subject areas

Medicine (miscellaneous)
Materials Science (miscellaneous)
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Agricultural and Biological Sciences (miscellaneous)
Physics and Astronomy (miscellaneous)
Space and Planetary Science

Access to Document

10.1038/s41526-023-00289-w

Cite this

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title = "Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice",

abstract = "The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.",

keywords = "Space research, Hind limb unloading, Radiation exposure, Skeletal muscle, Myeloid cells",

author = "Emanuelsson, {Eric B.} and Bjorn Baselet and Mieke Neefs and Sarah Baatout and Brit Proesmans and Lisa Daenen and Sundberg, {Carl Johan} and Helene Rundqvist and Rodrigo Fernandez-Gonzalo",

note = "Score=10 Funding Information: The experiments described in this manuscript were partly funded by ESA/BELSPO/Prodex, IMPULSE contract CO-90-11-2801-04, and the European Low Gravity Research Association in the form of the research prize 2020-2021. R.F.G. is supported by a career grant from the Swedish National Space Agency (2021-00159). Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

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doi = "10.1038/s41526-023-00289-w",

language = "English",

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T1 - Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

AU - Emanuelsson, Eric B.

AU - Baselet, Bjorn

AU - Neefs, Mieke

AU - Baatout, Sarah

AU - Proesmans, Brit

AU - Daenen, Lisa

AU - Sundberg, Carl Johan

AU - Rundqvist, Helene

AU - Fernandez-Gonzalo, Rodrigo

N1 - Score=10 Funding Information: The experiments described in this manuscript were partly funded by ESA/BELSPO/Prodex, IMPULSE contract CO-90-11-2801-04, and the European Low Gravity Research Association in the form of the research prize 2020-2021. R.F.G. is supported by a career grant from the Swedish National Space Agency (2021-00159). Publisher Copyright: © 2023, The Author(s).

PY - 2023/12

Y1 - 2023/12

N2 - The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.

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KW - Myeloid cells

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