Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

Eric B. Emanuelsson, Bjorn Baselet, Mieke Neefs, Sarah Baatout, Brit Proesmans, Lisa Daenen, Carl Johan Sundberg, Helene Rundqvist, Rodrigo Fernandez-Gonzalo

    Research outputpeer-review


    The skeletal muscle and the immune system are heavily affected by the space environment. The crosstalk between these organs, although established, is not fully understood. This study determined the nature of immune cell changes in the murine skeletal muscle following (hindlimb) unloading combined with an acute session of irradiation (HLUR). Our findings show that 14 days of HLUR induces a significant increase of myeloid immune cell infiltration in skeletal muscle.

    Original languageEnglish
    Article number40
    Number of pages4
    Journalnpj Microgravity
    Issue number1
    StatePublished - Dec 2023

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Materials Science (miscellaneous)
    • Biochemistry, Genetics and Molecular Biology (miscellaneous)
    • Agricultural and Biological Sciences (miscellaneous)
    • Physics and Astronomy (miscellaneous)
    • Space and Planetary Science

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