MYRRHA (Multi-purpose hYbrid Research Reactor for High-tech Applications) is the flexible experimental Accelerator-Driven System (ADS) currently under development at SCKCEN and will replace the Material Testing Reactor (MTR) BR2. The MYRRHA facility is currently being developed with the aid of the FP7- project ‘‘Central Design Team’’ and will be as a flexible irradiation facility, able to work in both subcritical and critical modes. In this way, MYRRHA will allow fuel developments for innovative reactor systems, material developments for GEN IV systems, material developments for fusion reactors, radioisotope production for medical and industrial applications, and Si-doping. MYRRHA will also demonstrate the full concept of ADS by coupling the requisite 3 components (accelerator, spallation target and subcritical reactor) at reasonable power level to allow operation feedback, scalable to an industrial demonstrator and allow for the study of efficient transmutation of high-level nuclear waste. Since MYRRHA is based on the heavy liquid metal technology, LBi Eutectic, it will be able to significantly contribute to the development of Lead Fast Reactor (LFR) technology. Further, in critical mode, MYRRHA will play the role of European Technology Pilot Plant in the path forward for LFR.