Naturally occurring, postnatal cell death in the cerebral cortex of the micrencephalic rat induced by prenatal X-irradiation

Isidró A. Ferrer; Eduardo Soriano; E. Martí; Encarna Laforet; H. Reyners; E. Gianfelici de Reyners

doi:10.1016/0168-0102(91)90076-B

Naturally occurring, postnatal cell death in the cerebral cortex of the micrencephalic rat induced by prenatal X-irradiation

Isidró A. Ferrer, Eduardo Soriano, E. Martí, Encarna Laforet, H. Reyners, E. Gianfelici de Reyners

Research output › peer-review

Abstract

Naturally occurring postnatal cell death in the somatosensory cortex and medial cortical areas was examined in micrencephalic rats produced after exposure to 100 cGy X-rays at embryonic day 15. The absolute numbers of dead cells per tissue section were not affected in the future subcortical white matter, but were severely decreased in the cerebral cortex when compared with age-matched controls. Furthermore, the proportion of cortical dead cells per 1000 live neurons in the cerebral cortex and the cumulative cell death across time were significantly reduced in irradiated animals. These results suggest that naturally occurring postnatal cell death in the cerebral cortex is reduced in micrencephaly.

Original language	English
Pages (from-to)	446-451
Number of pages	6
Journal	Neuroscience Research
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/0168-0102(91)90076-B
State	Published - Nov 1991

Funding

We wish to thank Drs. M.C. Lizuain, C. Cinos and I. Febrifin from the Service of Physics and Radiation Protection for measurement of the doses in irradiation of the animals, and Mr. L. Barnett for linguistic advice. This work was supported by the RTD Programme B17-0003-C (CEC) and by grant FIS 90E1263.

Funders	Funder number
Not added	FIS 90E1263

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0168-0102(91)90076-B

Cite this

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title = "Naturally occurring, postnatal cell death in the cerebral cortex of the micrencephalic rat induced by prenatal X-irradiation",

abstract = "Naturally occurring postnatal cell death in the somatosensory cortex and medial cortical areas was examined in micrencephalic rats produced after exposure to 100 cGy X-rays at embryonic day 15. The absolute numbers of dead cells per tissue section were not affected in the future subcortical white matter, but were severely decreased in the cerebral cortex when compared with age-matched controls. Furthermore, the proportion of cortical dead cells per 1000 live neurons in the cerebral cortex and the cumulative cell death across time were significantly reduced in irradiated animals. These results suggest that naturally occurring postnatal cell death in the cerebral cortex is reduced in micrencephaly.",

keywords = "Cerebral cortex, Micrencephaly, Naturally occurring cell death, X-irradiation",

author = "Ferrer, {Isidr{\'o} A.} and Eduardo Soriano and E. Mart{\'i} and Encarna Laforet and H. Reyners and {Gianfelici de Reyners}, E.",

year = "1991",

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doi = "10.1016/0168-0102(91)90076-B",

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T1 - Naturally occurring, postnatal cell death in the cerebral cortex of the micrencephalic rat induced by prenatal X-irradiation

AU - Ferrer, Isidró A.

AU - Soriano, Eduardo

AU - Martí, E.

AU - Laforet, Encarna

AU - Reyners, H.

AU - Gianfelici de Reyners, E.

PY - 1991/11

Y1 - 1991/11

N2 - Naturally occurring postnatal cell death in the somatosensory cortex and medial cortical areas was examined in micrencephalic rats produced after exposure to 100 cGy X-rays at embryonic day 15. The absolute numbers of dead cells per tissue section were not affected in the future subcortical white matter, but were severely decreased in the cerebral cortex when compared with age-matched controls. Furthermore, the proportion of cortical dead cells per 1000 live neurons in the cerebral cortex and the cumulative cell death across time were significantly reduced in irradiated animals. These results suggest that naturally occurring postnatal cell death in the cerebral cortex is reduced in micrencephaly.

AB - Naturally occurring postnatal cell death in the somatosensory cortex and medial cortical areas was examined in micrencephalic rats produced after exposure to 100 cGy X-rays at embryonic day 15. The absolute numbers of dead cells per tissue section were not affected in the future subcortical white matter, but were severely decreased in the cerebral cortex when compared with age-matched controls. Furthermore, the proportion of cortical dead cells per 1000 live neurons in the cerebral cortex and the cumulative cell death across time were significantly reduced in irradiated animals. These results suggest that naturally occurring postnatal cell death in the cerebral cortex is reduced in micrencephaly.

KW - Cerebral cortex

KW - Micrencephaly

KW - Naturally occurring cell death

KW - X-irradiation

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