Abstract
Naturally occurring postnatal cell death in the somatosensory cortex and medial cortical areas was examined in micrencephalic rats produced after exposure to 100 cGy X-rays at embryonic day 15. The absolute numbers of dead cells per tissue section were not affected in the future subcortical white matter, but were severely decreased in the cerebral cortex when compared with age-matched controls. Furthermore, the proportion of cortical dead cells per 1000 live neurons in the cerebral cortex and the cumulative cell death across time were significantly reduced in irradiated animals. These results suggest that naturally occurring postnatal cell death in the cerebral cortex is reduced in micrencephaly.
Original language | English |
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Pages (from-to) | 446-451 |
Number of pages | 6 |
Journal | Neuroscience Research |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Nov 1991 |
Funding
We wish to thank Drs. M.C. Lizuain, C. Cinos and I. Febrifin from the Service of Physics and Radiation Protection for measurement of the doses in irradiation of the animals, and Mr. L. Barnett for linguistic advice. This work was supported by the RTD Programme B17-0003-C (CEC) and by grant FIS 90E1263.
Funders | Funder number |
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Not added | FIS 90E1263 |
ASJC Scopus subject areas
- General Neuroscience