Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline

Isabeau De Bie; Lisa Berden; Bo Peeters; Christian Vanhove; Tom Boterberg; Kevin Tabury; Irina Primac; Robrecht Raedt; Rafi Benotmane

doi:10.1093/neuonc/noae144.243

Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline

Isabeau De Bie, Lisa Berden, Bo Peeters, Christian Vanhove, Tom Boterberg, Kevin Tabury, Irina Primac, Robrecht Raedt, Rafi Benotmane

Radiobiology

Research output › peer-review

Abstract

Pediatric patients undergoing cranial irradiation are at risk of developing neurocognitive impairments. Mechanistically, radiation-induced injury to the hippocampi could play an important role in this debilitating condition, by inducing loss of neural stem/progenitor cells and neuroinflammation within this region. Noradrenergic (NA) agonists can potentially mitigate this radiation-induced cognitive decline by reducing cell death and inflammation. Therefore, we hypothesize that boosting NA through drugs will attenuate radiation-induced impairments in neurogenesis and decrease neuroinflammation, resulting in decreased memory dysfunction.

Original language	English
Title of host publication	Abstracts from the 19th Meeting of the European Association of Neuro-Oncology
Publisher	Oxford University Press
Pages	V73-V74
Number of pages	2
DOIs	https://doi.org/10.1093/neuonc/noae144.243
State	Published - Oct 2024
Event	2024 - EANO: 19th Meeting of the European Association of Neuro-Oncology - Glasgow Duration: 17 Oct 2024 → 20 Oct 2024 https://www.eano.eu/eano2024/

Publication series

Name	Neuro-Oncology
Publisher	Oxford University Press
Number	supplement 5
Volume	26
ISSN (Print)	1522-851
ISSN (Electronic)	1523-5866

Conference

Conference	2024 - EANO
Country/Territory	United Kingdom
City	Glasgow
Period	2024-10-17 → 2024-10-20
Internet address	https://www.eano.eu/eano2024/

Access to Document

10.1093/neuonc/noae144.243License: Unspecified

Cite this

De Bie, I., Berden, L., Peeters, B., Vanhove, C., Boterberg, T., Tabury, K., Primac, I., Raedt, R., & Benotmane, R. (2024). Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline. In Abstracts from the 19th Meeting of the European Association of Neuro-Oncology (pp. V73-V74). Article P13.10 (Neuro-Oncology; Vol. 26, No. supplement 5). Oxford University Press. https://doi.org/10.1093/neuonc/noae144.243

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title = "Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline",

abstract = "Pediatric patients undergoing cranial irradiation are at risk of developing neurocognitive impairments. Mechanistically, radiation-induced injury to the hippocampi could play an important role in this debilitating condition, by inducing loss of neural stem/progenitor cells and neuroinflammation within this region. Noradrenergic (NA) agonists can potentially mitigate this radiation-induced cognitive decline by reducing cell death and inflammation. Therefore, we hypothesize that boosting NA through drugs will attenuate radiation-induced impairments in neurogenesis and decrease neuroinflammation, resulting in decreased memory dysfunction. ",

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De Bie, I, Berden, L , Peeters, B, Vanhove, C, Boterberg, T, Tabury, K , Primac, I, Raedt, R & Benotmane, R 2024, Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline. in Abstracts from the 19th Meeting of the European Association of Neuro-Oncology., P13.10, Neuro-Oncology, no. supplement 5, vol. 26, Oxford University Press, pp. V73-V74, 2024 - EANO, Glasgow, United Kingdom, 2024-10-17. https://doi.org/10.1093/neuonc/noae144.243

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T1 - Noradrenergic agonists as new treatment opportunity against radiation-induced cognitive decline

AU - De Bie, Isabeau

AU - Berden, Lisa

AU - Peeters, Bo

AU - Vanhove, Christian

AU - Boterberg, Tom

AU - Tabury, Kevin

AU - Primac, Irina

AU - Raedt, Robrecht

AU - Benotmane, Rafi

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Y1 - 2024/10

N2 - Pediatric patients undergoing cranial irradiation are at risk of developing neurocognitive impairments. Mechanistically, radiation-induced injury to the hippocampi could play an important role in this debilitating condition, by inducing loss of neural stem/progenitor cells and neuroinflammation within this region. Noradrenergic (NA) agonists can potentially mitigate this radiation-induced cognitive decline by reducing cell death and inflammation. Therefore, we hypothesize that boosting NA through drugs will attenuate radiation-induced impairments in neurogenesis and decrease neuroinflammation, resulting in decreased memory dysfunction.

AB - Pediatric patients undergoing cranial irradiation are at risk of developing neurocognitive impairments. Mechanistically, radiation-induced injury to the hippocampi could play an important role in this debilitating condition, by inducing loss of neural stem/progenitor cells and neuroinflammation within this region. Noradrenergic (NA) agonists can potentially mitigate this radiation-induced cognitive decline by reducing cell death and inflammation. Therefore, we hypothesize that boosting NA through drugs will attenuate radiation-induced impairments in neurogenesis and decrease neuroinflammation, resulting in decreased memory dysfunction.

KW - Pediatric patients

KW - Irradiation

U2 - 10.1093/neuonc/noae144.243

DO - 10.1093/neuonc/noae144.243

M3 - In-proceedings paper

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BT - Abstracts from the 19th Meeting of the European Association of Neuro-Oncology

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