Nucleotide sequence of the envelope gene of radiation leukemia virus

J. Merregaert; J. M. Nuyten; M. Janowski

doi:10.1016/0042-6822(85)90286-7

Nucleotide sequence of the envelope gene of radiation leukemia virus

J. Merregaert
, J. M. Nuyten
, M. Janowski

Research output › peer-review

Abstract

The nucleotide sequence and the predicted amino acid sequence of the envelope gene (env) of RadLV/VL₃ (T⁺L⁺) has been determined. RadLV/VL₃ (T⁺L⁺) is a highly thymotropic (T⁺) and leukemogenic (L⁺) murine recombinant retrovirus continuously produced at high titer by BL/VL₃ cells, a line established in culture from a radiation leukemia virus (RadLV)-induced C57BL/Ka mouse thymic lymphoma. The envelope gene is strikingly similar (92% homologous) to that encoded by the ecotropic Akv-MuLV. Among the differences, 134 scattered, although unevenly distributed point mutations (6.4%), two 9-bp deletions as well as a 6-bp insertion were observed (which result in 49 amino acid changes in the env gene of RadLV/VL₃ (T⁺L⁺)).

Original language	English
Pages (from-to)	457-467
Number of pages	11
Journal	Virology
Volume	144
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(85)90286-7
State	Published - 30 Jul 1985

ASJC Scopus subject areas

Virology

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10.1016/0042-6822(85)90286-7

Cite this

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title = "Nucleotide sequence of the envelope gene of radiation leukemia virus",

abstract = "The nucleotide sequence and the predicted amino acid sequence of the envelope gene (env) of RadLV/VL3 (T+L+) has been determined. RadLV/VL3 (T+L+) is a highly thymotropic (T+) and leukemogenic (L+) murine recombinant retrovirus continuously produced at high titer by BL/VL3 cells, a line established in culture from a radiation leukemia virus (RadLV)-induced C57BL/Ka mouse thymic lymphoma. The envelope gene is strikingly similar (92\% homologous) to that encoded by the ecotropic Akv-MuLV. Among the differences, 134 scattered, although unevenly distributed point mutations (6.4\%), two 9-bp deletions as well as a 6-bp insertion were observed (which result in 49 amino acid changes in the env gene of RadLV/VL3 (T+L+)).",

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T1 - Nucleotide sequence of the envelope gene of radiation leukemia virus

AU - Merregaert, J.

AU - Nuyten, J. M.

AU - Janowski, M.

PY - 1985/7/30

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N2 - The nucleotide sequence and the predicted amino acid sequence of the envelope gene (env) of RadLV/VL3 (T+L+) has been determined. RadLV/VL3 (T+L+) is a highly thymotropic (T+) and leukemogenic (L+) murine recombinant retrovirus continuously produced at high titer by BL/VL3 cells, a line established in culture from a radiation leukemia virus (RadLV)-induced C57BL/Ka mouse thymic lymphoma. The envelope gene is strikingly similar (92% homologous) to that encoded by the ecotropic Akv-MuLV. Among the differences, 134 scattered, although unevenly distributed point mutations (6.4%), two 9-bp deletions as well as a 6-bp insertion were observed (which result in 49 amino acid changes in the env gene of RadLV/VL3 (T+L+)).

AB - The nucleotide sequence and the predicted amino acid sequence of the envelope gene (env) of RadLV/VL3 (T+L+) has been determined. RadLV/VL3 (T+L+) is a highly thymotropic (T+) and leukemogenic (L+) murine recombinant retrovirus continuously produced at high titer by BL/VL3 cells, a line established in culture from a radiation leukemia virus (RadLV)-induced C57BL/Ka mouse thymic lymphoma. The envelope gene is strikingly similar (92% homologous) to that encoded by the ecotropic Akv-MuLV. Among the differences, 134 scattered, although unevenly distributed point mutations (6.4%), two 9-bp deletions as well as a 6-bp insertion were observed (which result in 49 amino acid changes in the env gene of RadLV/VL3 (T+L+)).

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