GUINEVERE provides a zero power Accelerator Driven System at present mainly dedicated to the investigation of on-line reactivity monitoring and operational procedures of an ADS in the framework of the FP7 FREYA project. It was launched and constructed in the framework of FP 6 IP-EUROTRANS, as a follow up of the MUSE program, and was supported by SCK•CEN, the PACEN CNRS program, and CEA . GUINEVERE couples an electrostatic particle accelerator GENEPI-3C to a fast sub-critical nuclear reactor VENUS-F at SCK•CEN. GENEPI-3C consists of a duoplasmatron source, an electrostatic accelerator tube, and an optical line (dipole, quadrupoles and steerers), which has horizontal and vertical sections, and guides the beam to a tritium target located inside the VENUS reactor. After the first coupling of GENEPI-3C and VENUS-F in October 2011, a lot of data from the accelerator has been recorded and some improvements have been achieved, especially concerning the stability of beam production. The accelerator was operated in three different beam modes at 220 kV: pulses, continuous and chopped mode. We present the first results of the operation of GENEPI-3C coupled with VENUS-F.