TY - JOUR
T1 - Out‑of‑field effects: lessons learned from partial body exposure
AU - Pazzaglia, Simonetta
AU - Eidemüller, Markus
AU - Lumniczky, Katalin
AU - Mancuso, Mariateresa
AU - Ramadan, Raghda
AU - Stolarczyk, Liliana
AU - Moertl, Simone
N1 - Score=10
PY - 2022/8/24
Y1 - 2022/8/24
N2 - Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.
AB - Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.
KW - Cardiovascular disease
KW - Extracellular vesicles
KW - Brain
KW - Radiation dosimetry
KW - Out-of-field d
KW - Systemic radiation effects
KW - Immune cel
KW - Secondary cancer
UR - https://ecm.sckcen.be/OTCS/llisapi.dll/overview/50723166
U2 - 10.1007/s00411-022-00988-0
DO - 10.1007/s00411-022-00988-0
M3 - Article
SN - 0301-634X
VL - 61
SP - 485
EP - 504
JO - Radiation and Environmental Biophysics
JF - Radiation and Environmental Biophysics
M1 - + correction
ER -