Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now

Katie M. Harris; Arya Roopen; Antoinea Elias; Tobias Weber; David A. Green; Danielle K. Greaves; Lonnie G. Petersen; Lara Roberts; Tovy Haber Kamine; Lucia Mazzolai; Andrej Bergauer; David S. Kim; Rik H. Olde Engberink; Peter zu Eulenberg; Bruno Grassi; Lucrezia Zuccarelli; Giovanni Baldassarre; Kevin Tabury; Sarah Baatout; Jens Jordan; Andrew P. Blaber; Alexander Choukèr; Thais Russomano; Nandu Goswami

doi:10.1038/s41526-023-00260-9

Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now

Katie M. Harris, Arya Roopen, Antoinea Elias, Tobias Weber, David A. Green, Danielle K. Greaves, Lonnie G. Petersen, Lara Roberts, Tovy Haber Kamine, Lucia Mazzolai, Andrej Bergauer, David S. Kim, Rik H. Olde Engberink, Peter zu Eulenberg, Bruno Grassi, Lucrezia Zuccarelli, Giovanni Baldassarre, Kevin Tabury, Sarah Baatout, Jens JordanAndrew P. Blaber, Alexander Choukèr, Thais Russomano, Nandu Goswami

Research output › peer-review

Abstract

The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.

Original language	English
Article number	17
Number of pages	7
Journal	npj Microgravity
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41526-023-00260-9
State	Published - Dec 2023

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Agricultural and Biological Sciences (miscellaneous)
Medicine (miscellaneous)
Space and Planetary Science
Materials Science (miscellaneous)
Physics and Astronomy (miscellaneous)

Access to Document

10.1038/s41526-023-00260-9

Cite this

Harris, K. M., Roopen, A., Elias, A., Weber, T., Green, D. A., Greaves, D. K., Petersen, L. G., Roberts, L., Kamine, T. H., Mazzolai, L., Bergauer, A., Kim, D. S., Olde Engberink, R. H., Eulenberg, P. Z., Grassi, B., Zuccarelli, L., Baldassarre, G., Tabury, K., Baatout, S., ... Goswami, N. (2023). Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now. npj Microgravity, 9(1), Article 17. https://doi.org/10.1038/s41526-023-00260-9

@article{9668ded84ed44fd6938ee40066c9d43d,

title = "Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now",

abstract = "The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.",

keywords = "Venous thrombosis (VT), Pathophysiology, Space, ISS",

author = "Harris, {Katie M.} and Arya Roopen and Antoinea Elias and Tobias Weber and Green, {David A.} and Greaves, {Danielle K.} and Petersen, {Lonnie G.} and Lara Roberts and Kamine, {Tovy Haber} and Lucia Mazzolai and Andrej Bergauer and Kim, {David S.} and {Olde Engberink}, {Rik H.} and Eulenberg, {Peter zu} and Bruno Grassi and Lucrezia Zuccarelli and Giovanni Baldassarre and Kevin Tabury and Sarah Baatout and Jens Jordan and Blaber, {Andrew P.} and Alexander Chouk{\`e}r and Thais Russomano and Nandu Goswami",

note = "Score=10 Funding Information: The authors would like to acknowledge the members of the topical team who contributed to the ideas and recommendations provided in this manuscript: ESA VT Topical Team Members. A.B. A.P.B. Andrew Winnard. Angelique Van Ombergen. A.E. Bianca Brix. B.G. D.K.G. D.A.G. D.S.K. Gerhard Cvirn. Giovanni Baldasarre. Guy Meyer. Hanns-Christian Gunga. James Pavela. J.J. Jens Tank. Jutta G{\"a}rtner. K.M.H. Kristina Kofler. L.R. L.G.P. L.M. L.Z. Myles George Harris. Patrick De Boever. P.z.E. Rado Pi{\v s}ot. Robert Riddell. Roopen Arya. Sargsyan Ashot. Sergi Vaquer. Setfan Du Plessis. T.W. T.H.K. Ulrich Limper. We are thankful to the European Space Agency and NASA for financial support of this project. The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI. The project was funded by the European Space Agency and KBR GmbH. The funder (KBR GmbH) provided support in the form of salaries for the authors T.W. and D.A.G. but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: The authors would like to acknowledge the members of the topical team who contributed to the ideas and recommendations provided in this manuscript: ESA VT Topical Team Members. A.B. A.P.B. Andrew Winnard. Angelique Van Ombergen. A.E. Bianca Brix. B.G. D.K.G. D.A.G. D.S.K. Gerhard Cvirn. Giovanni Baldasarre. Guy Meyer. Hanns-Christian Gunga. James Pavela. J.J. Jens Tank. Jutta G{\"a}rtner. K.M.H. Kristina Kofler. L.R. L.G.P. L.M. L.Z. Myles George Harris. Patrick De Boever. P.z.E. Rado Pi{\v s}ot. Robert Riddell. Roopen Arya. Sargsyan Ashot. Sergi Vaquer. Setfan Du Plessis. T.W. T.H.K. Ulrich Limper. We are thankful to the European Space Agency and NASA for financial support of this project. The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI. The project was funded by the European Space Agency and KBR GmbH. The funder (KBR GmbH) provided support in the form of salaries for the authors T.W. and D.A.G. but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = dec,

doi = "10.1038/s41526-023-00260-9",

language = "English",

volume = "9",

journal = "npj Microgravity",

issn = "2373-8065",

publisher = "Nature Portfolio",

number = "1",

}

Harris, KM, Roopen, A, Elias, A, Weber, T, Green, DA, Greaves, DK, Petersen, LG, Roberts, L, Kamine, TH, Mazzolai, L, Bergauer, A, Kim, DS, Olde Engberink, RH, Eulenberg, PZ, Grassi, B, Zuccarelli, L, Baldassarre, G, Tabury, K , Baatout, S, Jordan, J, Blaber, AP, Choukèr, A, Russomano, T & Goswami, N 2023, 'Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now', npj Microgravity, vol. 9, no. 1, 17. https://doi.org/10.1038/s41526-023-00260-9

TY - JOUR

T1 - Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now

AU - Harris, Katie M.

AU - Roopen, Arya

AU - Elias, Antoinea

AU - Weber, Tobias

AU - Green, David A.

AU - Greaves, Danielle K.

AU - Petersen, Lonnie G.

AU - Roberts, Lara

AU - Kamine, Tovy Haber

AU - Mazzolai, Lucia

AU - Bergauer, Andrej

AU - Kim, David S.

AU - Olde Engberink, Rik H.

AU - Eulenberg, Peter zu

AU - Grassi, Bruno

AU - Zuccarelli, Lucrezia

AU - Baldassarre, Giovanni

AU - Tabury, Kevin

AU - Baatout, Sarah

AU - Jordan, Jens

AU - Blaber, Andrew P.

AU - Choukèr, Alexander

AU - Russomano, Thais

AU - Goswami, Nandu

N1 - Score=10 Funding Information: The authors would like to acknowledge the members of the topical team who contributed to the ideas and recommendations provided in this manuscript: ESA VT Topical Team Members. A.B. A.P.B. Andrew Winnard. Angelique Van Ombergen. A.E. Bianca Brix. B.G. D.K.G. D.A.G. D.S.K. Gerhard Cvirn. Giovanni Baldasarre. Guy Meyer. Hanns-Christian Gunga. James Pavela. J.J. Jens Tank. Jutta Gärtner. K.M.H. Kristina Kofler. L.R. L.G.P. L.M. L.Z. Myles George Harris. Patrick De Boever. P.z.E. Rado Pišot. Robert Riddell. Roopen Arya. Sargsyan Ashot. Sergi Vaquer. Setfan Du Plessis. T.W. T.H.K. Ulrich Limper. We are thankful to the European Space Agency and NASA for financial support of this project. The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI. The project was funded by the European Space Agency and KBR GmbH. The funder (KBR GmbH) provided support in the form of salaries for the authors T.W. and D.A.G. but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: The authors would like to acknowledge the members of the topical team who contributed to the ideas and recommendations provided in this manuscript: ESA VT Topical Team Members. A.B. A.P.B. Andrew Winnard. Angelique Van Ombergen. A.E. Bianca Brix. B.G. D.K.G. D.A.G. D.S.K. Gerhard Cvirn. Giovanni Baldasarre. Guy Meyer. Hanns-Christian Gunga. James Pavela. J.J. Jens Tank. Jutta Gärtner. K.M.H. Kristina Kofler. L.R. L.G.P. L.M. L.Z. Myles George Harris. Patrick De Boever. P.z.E. Rado Pišot. Robert Riddell. Roopen Arya. Sargsyan Ashot. Sergi Vaquer. Setfan Du Plessis. T.W. T.H.K. Ulrich Limper. We are thankful to the European Space Agency and NASA for financial support of this project. The European Space Agency provided funding to cover the open access cost of this publication. Publication costs were covered specifically from the ESA-sponsored Topical Team on “Pathophysiology, risk and clinical presentation of venous thromboembolism (VTE) and its evaluation of its prevention, diagnosis, mitigation and management strategies in spaceflight” (Grant number 4000131108/20/NL/PG/pt) and NASA Grant number 80NSSC19K0020, PI. The project was funded by the European Space Agency and KBR GmbH. The funder (KBR GmbH) provided support in the form of salaries for the authors T.W. and D.A.G. but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2023, The Author(s).

PY - 2023/12

Y1 - 2023/12

N2 - The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.

AB - The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.

KW - Venous thrombosis (VT)

KW - Pathophysiology

KW - Space

KW - ISS

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/54244260

U2 - 10.1038/s41526-023-00260-9

DO - 10.1038/s41526-023-00260-9

M3 - Article

SN - 2373-8065

VL - 9

JO - npj Microgravity

JF - npj Microgravity

IS - 1

M1 - 17

ER -