Pathophysiology, risk, diagnosis, and management of venous thrombosis in space: where are we now

Katie M. Harris, Arya Roopen, Antoinea Elias, Tobias Weber, David A. Green, Danielle K. Greaves, Lonnie G. Petersen, Lara Roberts, Tovy Haber Kamine, Lucia Mazzolai, Andrej Bergauer, David S. Kim, Rik H. Olde Engberink, Peter zu Eulenberg, Bruno Grassi, Lucrezia Zuccarelli, Giovanni Baldassarre, Kevin Tabury, Sarah Baatout, Jens JordanAndrew P. Blaber, Alexander Choukèr, Thais Russomano, Nandu Goswami

Research outputpeer-review


The recent incidental discovery of an asymptomatic venous thrombosis (VT) in the internal jugular vein of an astronaut on the International Space Station prompted a necessary, immediate response from the space medicine community. The European Space Agency formed a topical team to review the pathophysiology, risk and clinical presentation of venous thrombosis and the evaluation of its prevention, diagnosis, mitigation, and management strategies in spaceflight. In this article, we discuss the findings of the ESA VT Topical Team over its 2-year term, report the key gaps as we see them in the above areas which are hindering understanding VT in space. We provide research recommendations in a stepwise manner that build upon existing resources, and highlight the initial steps required to enable further evaluation of this newly identified pertinent medical risk.
Original languageEnglish
Article number17
Number of pages7
Journalnpj Microgravity
StatePublished - 16 Feb 2023

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