Phenotype of thymic lymphomas in the mouse

Roland Greimers; Anne Michel Rongy; Marie Paule Defresne; Jacques Boniver; Robert Hooghe

doi:10.1016/0145-2126(86)90297-3

Phenotype of thymic lymphomas in the mouse

Roland Greimers, Anne Michel Rongy, Marie Paule Defresne, Jacques Boniver, Robert Hooghe

Research output › peer-review

Abstract

The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2^-, L3T4^-; (2) Lyt-2⁺; L3T4^-; (3) Lyt-2^-, L3T4⁺; (4) Lyt2⁺, L3T4^-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.

Original language	English
Pages (from-to)	777-782
Number of pages	6
Journal	Leukemia Research
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/0145-2126(86)90297-3
State	Published - 1986

Funding

Funders	Funder number
FRS-FNRS - Fond national de la recherche scientifique

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Access to Document

10.1016/0145-2126(86)90297-3

Cite this

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title = "Phenotype of thymic lymphomas in the mouse",

abstract = "The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+; L3T4-; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.",

keywords = "cytofluorimetry, differentiation, lymphoma, T-lymphocyte",

author = "Roland Greimers and Rongy, {Anne Michel} and Defresne, {Marie Paule} and Jacques Boniver and Robert Hooghe",

year = "1986",

doi = "10.1016/0145-2126(86)90297-3",

language = "English",

volume = "10",

pages = "777--782",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd",

number = "7",

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TY - JOUR

T1 - Phenotype of thymic lymphomas in the mouse

AU - Greimers, Roland

AU - Rongy, Anne Michel

AU - Defresne, Marie Paule

AU - Boniver, Jacques

AU - Hooghe, Robert

PY - 1986

Y1 - 1986

N2 - The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+; L3T4-; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.

AB - The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+; L3T4-; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.

KW - cytofluorimetry

KW - differentiation

KW - lymphoma

KW - T-lymphocyte

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DO - 10.1016/0145-2126(86)90297-3

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AN - SCOPUS:0022495503

SN - 0145-2126

VL - 10

SP - 777

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JO - Leukemia Research

JF - Leukemia Research

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