Abstract
The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+; L3T4-; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 777-782 |
| Number of pages | 6 |
| Journal | Leukemia Research |
| Volume | 10 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1986 |
Funding
Establishing the phenotype and ascertaining the differentiation level of murine lymphomas is not an academic exercise. This information is badly needed if murine lymphoma is to be taken as a model for the study of normal lymphocyte differentiation and leukemogenesis [1]. For these studies, both fresh tumours * Supported by the Belgian Fund for Scientific Medical Research, by the Centre Anticanc6reux pr6s l'Universit6 de Li6ge, by the Radiation Protection Programme of the European Communities and by the European Late Effects Project Group. J.B. is senior research associate of the Belgian National Scientific Foundation (FNRS).
| Funders | Funder number |
|---|---|
| FRS-FNRS - Fond national de la recherche scientifique |
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research