Plasma hormone levels in normal and lead-treated pregnant mice

P. Jacquet; G. B. Gerber; A. Leonard; J. Maes

doi:10.1007/BF01920190

Plasma hormone levels in normal and lead-treated pregnant mice

P. Jacquet, G. B. Gerber, A. Leonard, J. Maes

Research output › peer-review

Abstract

Dietary lead (0.5%) was given to mice which, after mating, exhibited a vaginal plug. Estradiol, progesterone and prostaglandins E and F 2α were determined in, the plasma by radioimmuno assay at different times thereafter. The increase in estradiol and decrease in prostaglandins prior implantation are not greatly altered by lead treatment, whereas the subsequent increase in progesterone and later in estradiol is abolished. It is concluded that the lower number of pregnancies seen in lead-treated mothers is due to a maternal hormonal imbalance caused by lead.

Original language	English
Pages (from-to)	1375-1377
Number of pages	3
Journal	Experientia
Volume	33
Issue number	10
DOIs	https://doi.org/10.1007/BF01920190
State	Published - Oct 1977

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1007/BF01920190

Cite this

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title = "Plasma hormone levels in normal and lead-treated pregnant mice",

abstract = "Dietary lead (0.5%) was given to mice which, after mating, exhibited a vaginal plug. Estradiol, progesterone and prostaglandins E and F 2α were determined in, the plasma by radioimmuno assay at different times thereafter. The increase in estradiol and decrease in prostaglandins prior implantation are not greatly altered by lead treatment, whereas the subsequent increase in progesterone and later in estradiol is abolished. It is concluded that the lower number of pregnancies seen in lead-treated mothers is due to a maternal hormonal imbalance caused by lead.",

author = "P. Jacquet and Gerber, {G. B.} and A. Leonard and J. Maes",

year = "1977",

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AU - Gerber, G. B.

AU - Leonard, A.

AU - Maes, J.

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N2 - Dietary lead (0.5%) was given to mice which, after mating, exhibited a vaginal plug. Estradiol, progesterone and prostaglandins E and F 2α were determined in, the plasma by radioimmuno assay at different times thereafter. The increase in estradiol and decrease in prostaglandins prior implantation are not greatly altered by lead treatment, whereas the subsequent increase in progesterone and later in estradiol is abolished. It is concluded that the lower number of pregnancies seen in lead-treated mothers is due to a maternal hormonal imbalance caused by lead.

AB - Dietary lead (0.5%) was given to mice which, after mating, exhibited a vaginal plug. Estradiol, progesterone and prostaglandins E and F 2α were determined in, the plasma by radioimmuno assay at different times thereafter. The increase in estradiol and decrease in prostaglandins prior implantation are not greatly altered by lead treatment, whereas the subsequent increase in progesterone and later in estradiol is abolished. It is concluded that the lower number of pregnancies seen in lead-treated mothers is due to a maternal hormonal imbalance caused by lead.

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