Population monitoring for genetic damage induced by environmental physical and chemical agents

A. Leonard; Martine Duverger Van Bogaert; Alfred M. Bernard; M. Lambotte-Vandepaer; Robert R. Lauwerys

doi:10.1007/BF00399465

Population monitoring for genetic damage induced by environmental physical and chemical agents

A. Leonard, Martine Duverger Van Bogaert, Alfred M. Bernard, M. Lambotte-Vandepaer, Robert R. Lauwerys

Research output › peer-review

Abstract

The short-term tests performed in vitro on different systems, from phage to human cells, or in vivo, on laboratory animals, allow only a qualitative estimate of the action of mutagenic agents, and the extrapolation of such experimental results to man may encounter many difficulties. Direct biomonitoring of populations exposed to chemicals could represent a more realistic approach for an evaluation of the hazards to man. Certain methods are still under development. Nevertheless, other ones can already by used routinely, e.g. the cytogenetic observations on peripheral blood lymphocytes and the Ames test for mutagenic substances in urine, and can provide useful suggestions how to set threshold limits for chemical substances encountered in the working environment.

Original language	English
Pages (from-to)	369-384
Number of pages	16
Journal	Environmental Monitoring and Assessment
Volume	5
Issue number	4
DOIs	https://doi.org/10.1007/BF00399465
State	Published - Dec 1985

ASJC Scopus subject areas

General Environmental Science
Pollution
Management, Monitoring, Policy and Law

Access to Document

10.1007/BF00399465

Cite this

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title = "Population monitoring for genetic damage induced by environmental physical and chemical agents",

abstract = "The short-term tests performed in vitro on different systems, from phage to human cells, or in vivo, on laboratory animals, allow only a qualitative estimate of the action of mutagenic agents, and the extrapolation of such experimental results to man may encounter many difficulties. Direct biomonitoring of populations exposed to chemicals could represent a more realistic approach for an evaluation of the hazards to man. Certain methods are still under development. Nevertheless, other ones can already by used routinely, e.g. the cytogenetic observations on peripheral blood lymphocytes and the Ames test for mutagenic substances in urine, and can provide useful suggestions how to set threshold limits for chemical substances encountered in the working environment.",

author = "A. Leonard and Bogaert, {Martine Duverger Van} and Bernard, {Alfred M.} and M. Lambotte-Vandepaer and Lauwerys, {Robert R.}",

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AU - Leonard, A.

AU - Bogaert, Martine Duverger Van

AU - Bernard, Alfred M.

AU - Lambotte-Vandepaer, M.

AU - Lauwerys, Robert R.

PY - 1985/12

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