ra induced bone-cancers: The effects of a delayed na-alginate treatment

G. E.R. Schoeters; A. Luz; O. L.J. Vanderborght

doi:10.1080/09553008314550291

ra induced bone-cancers: The effects of a delayed na-alginate treatment

G. E.R. Schoeters, A. Luz, O. L.J. Vanderborght

Research output › peer-review

Abstract

At the present time no unequivocal evidence exists which shows that a reduction in the body-burden of a radionuclide by decorporative treatment results in a proportional decrease in the risk of long-term radiation effects. We have investigated the effectiveness of the daily administration of Na-alginate via the diet in removing ²²⁶Ra from the skeleton and in reducing the number of late effects such as osteosarcomas. The animals used were male C57Bl mice which had been injected with one of three different amounts of ²²⁶Ra (4·4, 10·7 or 24·8 kBq) four days prior to the onset of the decorporative treatment. The results showed that although this treatment was able to produce a substantial reduction in the ²²⁶Ra content of the mice it did not reduce the incidence of osteosarcoma. These results question the effectiveness of decorporation procedures initiated at longer times after contamination.

Original language	English
Pages (from-to)	231-247
Number of pages	17
Journal	International Journal of Radiation Biology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1080/09553008314550291
State	Published - 1983

Funding

Acknowledgments We thank Professor Dr . W . Gossner for the hospitality at his Neuherberg laboratories . We are grateful to A . Nickl for the preparation of the histological sections of bone tissue . We thank Dr . J . R . Maisin, M . Collier and C . Vangenechten for the soft tissue histology, and L . Tessens for expert technical assistance during the whole experiment . For the 226Ra measurements of the bones we thank J, . Colard, E . Blok, P . Vermeire and A . Verstrepen . The 226Ra measurements in eyes and liver were performed by J . Baton . W . Nicasi is acknowledged for help with radiographies . We are indebted to Dr . N . Priest for reading through the manuscript . This study is partly supported by Euratom contract 233-77-1 BLOB .

Funders	Funder number
Horizon Europe	233-77-1 BLOB

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1080/09553008314550291

Cite this

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abstract = "At the present time no unequivocal evidence exists which shows that a reduction in the body-burden of a radionuclide by decorporative treatment results in a proportional decrease in the risk of long-term radiation effects. We have investigated the effectiveness of the daily administration of Na-alginate via the diet in removing 226Ra from the skeleton and in reducing the number of late effects such as osteosarcomas. The animals used were male C57Bl mice which had been injected with one of three different amounts of 226Ra (4·4, 10·7 or 24·8 kBq) four days prior to the onset of the decorporative treatment. The results showed that although this treatment was able to produce a substantial reduction in the 226Ra content of the mice it did not reduce the incidence of osteosarcoma. These results question the effectiveness of decorporation procedures initiated at longer times after contamination.",

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AB - At the present time no unequivocal evidence exists which shows that a reduction in the body-burden of a radionuclide by decorporative treatment results in a proportional decrease in the risk of long-term radiation effects. We have investigated the effectiveness of the daily administration of Na-alginate via the diet in removing 226Ra from the skeleton and in reducing the number of late effects such as osteosarcomas. The animals used were male C57Bl mice which had been injected with one of three different amounts of 226Ra (4·4, 10·7 or 24·8 kBq) four days prior to the onset of the decorporative treatment. The results showed that although this treatment was able to produce a substantial reduction in the 226Ra content of the mice it did not reduce the incidence of osteosarcoma. These results question the effectiveness of decorporation procedures initiated at longer times after contamination.

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