Radioionidation reactions for radio pharmaceuticals: Compendium for effective synthesis strategies

Heinz H. Coenen; John Mertens; Bernard Mazieère; Peter Bläuenstein; Patrik Emond; Yves Frangin; Denis Guilloteau; Marielle Gysemans; Marcus Holschbach; Christian Loc'H; August P. Schubiger; Syed M. Qaim

doi:10.1007/1-4020-4561-1

Radioionidation reactions for radio pharmaceuticals: Compendium for effective synthesis strategies

Heinz H. Coenen, John Mertens, Bernard Mazieère, Peter Bläuenstein, Patrik Emond, Yves Frangin, Denis Guilloteau, Marielle Gysemans, Marcus Holschbach, Christian Loc'H, August P. Schubiger, Syed M. Qaim

Research output › peer-review

Abstract

Several of the around 30 radioisotopes of iodine find wide application in life sciences research both in vitro and in vivo. Most nuclear medicine departments possess one or more imaging devices for single-photon emission tomography (SPET).Molecules of biological interest, especially for functional imaging of metabolism and neurotransmission functions using SPET, are often labelled with ¹²³I. In this handbook, the major production routes of the six most relevant radioiodine isotopes are reviewed and various methods for labelling molecules of biological interest with radioiodine are described, including their basic reaction mechanisms. The influence of iodine introduction on physico-chemical, pharmaceutical and pharmacological properties of radiopharmaceuticals are discussed and corresponding examples of radioiodinated pharmaceutical preparations are given. Finally, an expert system providing guidelines for choosing the most appropriate method of radioiodination according to the chemical structure of the molecule of interest for tracer use is proposed.

Original language	English
Title of host publication	Radioionidation Reactions for Pharmaceuticals
Subtitle of host publication	Compendium for Effective Synthesis Strategies
Publisher	Springer Netherlands
Pages	1-101
Number of pages	101
ISBN (Print)	1402045603, 9781402045608
DOIs	https://doi.org/10.1007/1-4020-4561-1
State	Published - 2006

ASJC Scopus subject areas

General Materials Science
General Chemistry

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10.1007/1-4020-4561-1License: Unspecified

Cite this

Coenen, H. H., Mertens, J., Mazieère, B., Bläuenstein, P., Emond, P., Frangin, Y., Guilloteau, D., Gysemans, M., Holschbach, M., Loc'H, C., Schubiger, A. P., & Qaim, S. M. (2006). Radioionidation reactions for radio pharmaceuticals: Compendium for effective synthesis strategies. In Radioionidation Reactions for Pharmaceuticals: Compendium for Effective Synthesis Strategies (pp. 1-101). Springer Netherlands. https://doi.org/10.1007/1-4020-4561-1

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keywords = "Iodine, Radioisotopes, Radioiodine",

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Coenen, HH, Mertens, J, Mazieère, B, Bläuenstein, P, Emond, P, Frangin, Y, Guilloteau, D, Gysemans, M, Holschbach, M, Loc'H, C, Schubiger, AP & Qaim, SM 2006, Radioionidation reactions for radio pharmaceuticals: Compendium for effective synthesis strategies. in Radioionidation Reactions for Pharmaceuticals: Compendium for Effective Synthesis Strategies. Springer Netherlands, pp. 1-101. https://doi.org/10.1007/1-4020-4561-1

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AU - Frangin, Yves

AU - Guilloteau, Denis

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AU - Schubiger, August P.

AU - Qaim, Syed M.

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