Radiolabeling of Gold Nanoparticles With Lu-177 as a Platform for Cancer Theranostics

Noami Daems, Maarten Ooms, Thomas Cardinaels, Sarah Baatout, Carine Michiels, Stéphane Lucas, An Aerts

Research outputpeer-review


In cancer radiotherapy, gold nanoparticles (AuNPs) have emerged as promising radiosensitizers, which accumulate in the tumor and increase the effectiveness of external beam radiotherapy by local production of reactive oxygen species (ROS) and secondary electrons upon irradiation. Five nm gold nanoparticles surrounded by an organic shell of polyallylamine (PAA) are produced by plasma vapor deposition and are conjugated to anti-EGFR-antibodies (Cetuximab-Ctxb) for active tumor targeting (AuNPs-PAA-Ctxb). In order to increase the therapeutic effect of the AuNPs-PAA-Ctxb, we aim to radiolabel the nanoparticles with 177Lu.
Original languageEnglish
Title of host publicationAnnual Congress of the European Association of Nuclear Medicine October 12 – 16, 2019 Barcelona, Spain
Number of pages1
StatePublished - 31 Dec 2019

Publication series

NameEuropean Journal of Nuclear Medicine and Molecular Imaging
ISSN (Print)1619-7070

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