Radiolabeling with Tb-161 and Lu-177: defining the impact of metal impurities

Maarten Ooms; Andrew Burgoyne; Bernard Ponsard; Dennis Elema; Thomas Cardinaels; Michiel Van de Voorde

doi:10.1007/s00259-020-04988-4

Radiolabeling with Tb-161 and Lu-177: defining the impact of metal impurities

Maarten Ooms, Andrew Burgoyne, Bernard Ponsard, Dennis Elema, Thomas Cardinaels, Michiel Van de Voorde

Research output › peer-review

Abstract

161Tb and 177Lu prove to be highly valuable in the fight against cancer as they can be deployed in targeted radionuclide therapy. 177Lu-based radiopharmaceuticals are currently being widely explored, whereas interest in 161Tb as therapeutic radioisotope is growing rapidly because of its very comparable decay properties. Moreover, 161Tb is expected to have an improved therapeutic effect because of its simultaneous emission of conversion and Auger electron emission. SCK CEN recently developed in-house production methods for 161Tb [1] and 177Lu with high radionuclidic purity. However, also metal impurities are of major concern since they have the potential to compete with the radionuclide during radiolabeling. In this study we aimed to identify and quantify the effect of metal impurities on the radiolabeling of 161Tb and 177Lu.

Original language	English
Title of host publication	European Journal of Nuclear Medicine and Molecular Imaging
Pages	677
Number of pages	1
Volume	47
Edition	Supplement 1
DOIs	https://doi.org/10.1007/s00259-020-04988-4
State	Published - 30 Oct 2020
Event	2020 - EANM: European Association of Nuclear Medicine - Online Duration: 22 Oct 2020 → 30 Oct 2020 https://eanm20.eanm.org/

Publication series

Name	European Journal of Nuclear Medicine and Molecular Imaging
Publisher	Springer

Conference

Conference	2020 - EANM
Period	2020-10-22 → 2020-10-30
Internet address	https://eanm20.eanm.org/

Access to Document

10.1007/s00259-020-04988-4License: Unspecified

Cite this

Ooms, M., Burgoyne, A., Ponsard, B., Elema, D., Cardinaels, T., & Van de Voorde, M. (2020). Radiolabeling with Tb-161 and Lu-177: defining the impact of metal impurities. In European Journal of Nuclear Medicine and Molecular Imaging (Supplement 1 ed., Vol. 47, pp. 677). [EP-340] (European Journal of Nuclear Medicine and Molecular Imaging ). https://doi.org/10.1007/s00259-020-04988-4

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abstract = "161Tb and 177Lu prove to be highly valuable in the fight against cancer as they can be deployed in targeted radionuclide therapy. 177Lu-based radiopharmaceuticals are currently being widely explored, whereas interest in 161Tb as therapeutic radioisotope is growing rapidly because of its very comparable decay properties. Moreover, 161Tb is expected to have an improved therapeutic effect because of its simultaneous emission of conversion and Auger electron emission. SCK CEN recently developed in-house production methods for 161Tb [1] and 177Lu with high radionuclidic purity. However, also metal impurities are of major concern since they have the potential to compete with the radionuclide during radiolabeling. In this study we aimed to identify and quantify the effect of metal impurities on the radiolabeling of 161Tb and 177Lu.",

keywords = "Tb-161, Lu-177, Radionuclide therapy, Radiopharmaceuticals",

author = "Maarten Ooms and Andrew Burgoyne and Bernard Ponsard and Dennis Elema and Thomas Cardinaels and {Van de Voorde}, Michiel",

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Ooms, M, Burgoyne, A, Ponsard, B , Elema, D , Cardinaels, T & Van de Voorde, M 2020, Radiolabeling with Tb-161 and Lu-177: defining the impact of metal impurities. in European Journal of Nuclear Medicine and Molecular Imaging. Supplement 1 edn, vol. 47, EP-340, European Journal of Nuclear Medicine and Molecular Imaging , pp. 677, 2020 - EANM, 2020-10-22. https://doi.org/10.1007/s00259-020-04988-4

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AU - Elema, Dennis

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AU - Van de Voorde, Michiel

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AB - 161Tb and 177Lu prove to be highly valuable in the fight against cancer as they can be deployed in targeted radionuclide therapy. 177Lu-based radiopharmaceuticals are currently being widely explored, whereas interest in 161Tb as therapeutic radioisotope is growing rapidly because of its very comparable decay properties. Moreover, 161Tb is expected to have an improved therapeutic effect because of its simultaneous emission of conversion and Auger electron emission. SCK CEN recently developed in-house production methods for 161Tb [1] and 177Lu with high radionuclidic purity. However, also metal impurities are of major concern since they have the potential to compete with the radionuclide during radiolabeling. In this study we aimed to identify and quantify the effect of metal impurities on the radiolabeling of 161Tb and 177Lu.

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