Reciprocal lymphoid cell homing studies using wild and LPR (lymphoproliferation) mutant c57bl MICE

Encarnita Montecino Rodriguez; Obert J. Hooghe; Francis Loor

doi:10.3109/08916939009002978

Reciprocal lymphoid cell homing studies using wild and LPR (lymphoproliferation) mutant c57bl MICE

Encarnita Montecino Rodriguez, Obert J. Hooghe, Francis Loor

Research output › peer-review

Abstract

The injection of lymphoid cells from adult Ipr mice into normal and athymic congenic mice does not transfer the Ipr (lymphoproliferation) syndrome¹, We studied whether this phenomenon could be due to abnormal homing. The lymphoid cells from Ipr donors do not show a marked deficiency of migration to lymphoid organs in comparison with cells from Wild donors and a T-cell lymphona BL/VL₃. The lymphoid organs of Ipr recipients do not show an intrinsic abnormality as homing sites for lymphoid cells. The data reveal some minor migration preferences: the Ipr cells migrate better than Wild cells into Ipr lymph nodes (including athymic Ipr hosts), whereas Wild cells migrate slightly better than Ipr cells into Wild lymph nodes. In spite of such minor preferences, Wild cells can efficiently migrate into Ipr lymphoid organs, as well as Ipr cells into Wild lymphoid organs. Thus, the lack of transfer of lymphadenopathy in Wild recipients cannot be attributed to an alteration of Ipr cell homing.

Original language	English
Pages (from-to)	195-203
Number of pages	9
Journal	Autoimmunity
Volume	5
Issue number	3
DOIs	https://doi.org/10.3109/08916939009002978
State	Published - 1990
Externally published	Yes

Funding

This work was supported by a grant from the EURATOM noBlO-353-B, the Radiation Protection Research Programme of the Commission of the European Communities (Grant B- 160090-B), the European Late Effects Project Group, the Belgian Foundation for Medical Scientific Research (Grant 3.4533.88) and a CRE INSERM grant (Laboratoire d’Immunologie, Universite Louis Pasteur Strasbourg 1) .

Funders	Funder number
Horizon Europe
Not added	B- 160090-B
FRS-FNRS - Fond national de la recherche scientifique	3.4533.88

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.3109/08916939009002978

Cite this

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title = "Reciprocal lymphoid cell homing studies using wild and LPR (lymphoproliferation) mutant c57bl MICE",

abstract = "The injection of lymphoid cells from adult Ipr mice into normal and athymic congenic mice does not transfer the Ipr (lymphoproliferation) syndrome1, We studied whether this phenomenon could be due to abnormal homing. The lymphoid cells from Ipr donors do not show a marked deficiency of migration to lymphoid organs in comparison with cells from Wild donors and a T-cell lymphona BL/VL3. The lymphoid organs of Ipr recipients do not show an intrinsic abnormality as homing sites for lymphoid cells. The data reveal some minor migration preferences: the Ipr cells migrate better than Wild cells into Ipr lymph nodes (including athymic Ipr hosts), whereas Wild cells migrate slightly better than Ipr cells into Wild lymph nodes. In spite of such minor preferences, Wild cells can efficiently migrate into Ipr lymphoid organs, as well as Ipr cells into Wild lymphoid organs. Thus, the lack of transfer of lymphadenopathy in Wild recipients cannot be attributed to an alteration of Ipr cell homing.",

keywords = "Cell migration, Homing, Ipr locus, Mutant mouse",

author = "Rodriguez, {Encarnita Montecino} and Hooghe, {Obert J.} and Francis Loor",

year = "1990",

doi = "10.3109/08916939009002978",

language = "English",

volume = "5",

pages = "195--203",

journal = "Autoimmunity",

issn = "0891-6934",

publisher = "Taylor & Francis (CRC)",

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T1 - Reciprocal lymphoid cell homing studies using wild and LPR (lymphoproliferation) mutant c57bl MICE

AU - Rodriguez, Encarnita Montecino

AU - Hooghe, Obert J.

AU - Loor, Francis

PY - 1990

Y1 - 1990

N2 - The injection of lymphoid cells from adult Ipr mice into normal and athymic congenic mice does not transfer the Ipr (lymphoproliferation) syndrome1, We studied whether this phenomenon could be due to abnormal homing. The lymphoid cells from Ipr donors do not show a marked deficiency of migration to lymphoid organs in comparison with cells from Wild donors and a T-cell lymphona BL/VL3. The lymphoid organs of Ipr recipients do not show an intrinsic abnormality as homing sites for lymphoid cells. The data reveal some minor migration preferences: the Ipr cells migrate better than Wild cells into Ipr lymph nodes (including athymic Ipr hosts), whereas Wild cells migrate slightly better than Ipr cells into Wild lymph nodes. In spite of such minor preferences, Wild cells can efficiently migrate into Ipr lymphoid organs, as well as Ipr cells into Wild lymphoid organs. Thus, the lack of transfer of lymphadenopathy in Wild recipients cannot be attributed to an alteration of Ipr cell homing.

AB - The injection of lymphoid cells from adult Ipr mice into normal and athymic congenic mice does not transfer the Ipr (lymphoproliferation) syndrome1, We studied whether this phenomenon could be due to abnormal homing. The lymphoid cells from Ipr donors do not show a marked deficiency of migration to lymphoid organs in comparison with cells from Wild donors and a T-cell lymphona BL/VL3. The lymphoid organs of Ipr recipients do not show an intrinsic abnormality as homing sites for lymphoid cells. The data reveal some minor migration preferences: the Ipr cells migrate better than Wild cells into Ipr lymph nodes (including athymic Ipr hosts), whereas Wild cells migrate slightly better than Ipr cells into Wild lymph nodes. In spite of such minor preferences, Wild cells can efficiently migrate into Ipr lymphoid organs, as well as Ipr cells into Wild lymphoid organs. Thus, the lack of transfer of lymphadenopathy in Wild recipients cannot be attributed to an alteration of Ipr cell homing.

KW - Cell migration

KW - Homing

KW - Ipr locus

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