Relation between the X-ray dose and the rate of dominant lethals induced by irradiation of mouse spermatozoa

A. Léonard

doi:10.1016/0027-5107(66)90009-1

Relation between the X-ray dose and the rate of dominant lethals induced by irradiation of mouse spermatozoa

A. Léonard

Research output › peer-review

Abstract

Male mice received testicular irradiation with increasing doses from 100 to 6000 R of X-rays. After irradiation, each male was mated with 3 virgin females. Dissection of the females showed that the percentage of pregnant females decreases with the dose of X-irradiation received by the male. Our results show that the relationship between dominant lethal mutation rate and X-ray dose is linear. The ratio deaths before implantation/deaths after implantation increases only for high doses.

Original language	English
Pages (from-to)	73-78
Number of pages	6
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(66)90009-1
State	Published - Feb 1966

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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10.1016/0027-5107(66)90009-1

Cite this

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title = "Relation between the X-ray dose and the rate of dominant lethals induced by irradiation of mouse spermatozoa",

abstract = "Male mice received testicular irradiation with increasing doses from 100 to 6000 R of X-rays. After irradiation, each male was mated with 3 virgin females. Dissection of the females showed that the percentage of pregnant females decreases with the dose of X-irradiation received by the male. Our results show that the relationship between dominant lethal mutation rate and X-ray dose is linear. The ratio deaths before implantation/deaths after implantation increases only for high doses.",

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AB - Male mice received testicular irradiation with increasing doses from 100 to 6000 R of X-rays. After irradiation, each male was mated with 3 virgin females. Dissection of the females showed that the percentage of pregnant females decreases with the dose of X-irradiation received by the male. Our results show that the relationship between dominant lethal mutation rate and X-ray dose is linear. The ratio deaths before implantation/deaths after implantation increases only for high doses.

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