Over the past 15 years, some potential anticarcinogenic and anti-inflammatory effects of antioxidants have been defined. Antioxidants are known to act as powerful free-radical scavengers. Free radicals are able to induce DNA strand breaks and oxidative modifications of DNA bases and are produced naturally in the cell following a stress or respiration. The present preliminary study was undertaken in order to explore whether the product Duolife containing antioxidants could enhance apoptosis (or programmed cell death) in cancerous cells. Duolife was tested on two human cancerous cell lines: HELA (derived from cervix carcinoma) and IM-9 (derived from multiple myeloma) at various concentrations ranging from 0 to 500 µg/mL. The parameters investigated were cell proliferation, morphological changes and apoptosis.
|Number of pages||34|
|State||Published - 15 May 2006|
|Publisher||Studiecentrum voor Kernenergie|