Sites communs d'integration de provirus dans les lymphomes induits chez des souris C57BL par le virus des radioleucoses murines (RadLv) et absence de nouvelles sequences provirales dans l'adn des lymphomes radio-induits

M. Janowski, J. Boniver, J. R. Maisin

    Research outputpeer-review

    Abstract

    Radiation leukemia virus (RadLV)-induced lymphomas of C57BL mice display the appearance of novel proviral sequences at common sites of their DNAs. These results are compatible with the hypothesis of viral oncogenesis by promotor insertion. Radiation-induced tumors do not acquire a detectable novel provirus, suggesting that activation of a transforming gene proceeds by a mechanism distinct from the former.

    Translated title of the contributionCommon proviral integration sites in C57BL mouse lymphomas induced by RadLV and absence of novel proviral sequences in radiogenic lymphoma DNA
    Original languageFrench
    Pages (from-to)411-419
    Number of pages9
    JournalComptes Rendus des Seances de la Societe de Biologie et de ses Filiales
    Volume176
    Issue number3
    StatePublished - 1982

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology

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