Space Radiobiology

Christine Elisabeth Hellweg; Carmen Arena; Sarah Baatout; Bjorn Baselet; Kristina Beblo-Vranesevic; Nicol Caplin; Richard Coos; Fabiana Da Pieve; Veronica De Micco; Nicolas Foray; Boris Hespeels; Anne Catherine Heuskin; Jessica Kronenberg; Tetyana Milojevic; Silvana Miranda; Victoria Moris; Sébastien Penninckx; Wilhelmina E. Radstake; Emil Rehnberg; Petra Rettberg; Kevin Tabury; Karine Van Doninck; Olivier Van Hoey; Guillaume Vogin; Yehoshua Socol

doi:10.1007/978-3-031-18810-7_10

Space Radiobiology

Christine Elisabeth Hellweg, Carmen Arena, Sarah Baatout, Bjorn Baselet, Kristina Beblo-Vranesevic, Nicol Caplin, Richard Coos, Fabiana Da Pieve, Veronica De Micco, Nicolas Foray, Boris Hespeels, Anne Catherine Heuskin, Jessica Kronenberg, Tetyana Milojevic, Silvana Miranda, Victoria Moris, Sébastien Penninckx, Wilhelmina E. Radstake, Emil Rehnberg, Petra RettbergKevin Tabury, Karine Van Doninck, Olivier Van Hoey, Guillaume Vogin, Yehoshua Socol

Research output › peer-review

Abstract

The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

Original language	English
Title of host publication	Radiobiology Textbook
Publisher	Springer International Publishing
Pages	503-569
Number of pages	67
ISBN (Electronic)	9783031188107
ISBN (Print)	9783031188091
DOIs	https://doi.org/10.1007/978-3-031-18810-7_10
State	Published - 1 Jan 2023

ASJC Scopus subject areas

General Medicine
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

Access to Document

10.1007/978-3-031-18810-7_10

Cite this

Hellweg, C. E., Arena, C., Baatout, S., Baselet, B., Beblo-Vranesevic, K., Caplin, N., Coos, R., Da Pieve, F., De Micco, V., Foray, N., Hespeels, B., Heuskin, A. C., Kronenberg, J., Milojevic, T., Miranda, S., Moris, V., Penninckx, S., Radstake, W. E., Rehnberg, E., ... Socol, Y. (2023). Space Radiobiology. In Radiobiology Textbook (pp. 503-569). Springer International Publishing. https://doi.org/10.1007/978-3-031-18810-7_10

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abstract = "The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.",

keywords = "Cancer risk, Cataract, Chromosomal aberrations, Galactic cosmic rays (GCR), Light flashes, Monte Carlo methods, Particle accelerators, Radiation belts, Solar particle events (SPE)",

author = "Hellweg, {Christine Elisabeth} and Carmen Arena and Sarah Baatout and Bjorn Baselet and Kristina Beblo-Vranesevic and Nicol Caplin and Richard Coos and {Da Pieve}, Fabiana and {De Micco}, Veronica and Nicolas Foray and Boris Hespeels and Heuskin, {Anne Catherine} and Jessica Kronenberg and Tetyana Milojevic and Silvana Miranda and Victoria Moris and S{\'e}bastien Penninckx and Radstake, {Wilhelmina E.} and Emil Rehnberg and Petra Rettberg and Kevin Tabury and {Van Doninck}, Karine and {Van Hoey}, Olivier and Guillaume Vogin and Yehoshua Socol",

note = "Score=10 Publisher Copyright: {\textcopyright} The Editor(s) (if applicable) and The Author(s) 2023.",

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doi = "10.1007/978-3-031-18810-7_10",

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Hellweg, CE, Arena, C, Baatout, S , Baselet, B, Beblo-Vranesevic, K, Caplin, N, Coos, R, Da Pieve, F, De Micco, V, Foray, N, Hespeels, B, Heuskin, AC, Kronenberg, J, Milojevic, T, Miranda, S, Moris, V, Penninckx, S, Radstake, WE, Rehnberg, E, Rettberg, P, Tabury, K, Van Doninck, K, Van Hoey, O, Vogin, G & Socol, Y 2023, Space Radiobiology. in Radiobiology Textbook. Springer International Publishing, pp. 503-569. https://doi.org/10.1007/978-3-031-18810-7_10

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AU - Hellweg, Christine Elisabeth

AU - Arena, Carmen

AU - Baatout, Sarah

AU - Baselet, Bjorn

AU - Beblo-Vranesevic, Kristina

AU - Caplin, Nicol

AU - Coos, Richard

AU - Da Pieve, Fabiana

AU - De Micco, Veronica

AU - Foray, Nicolas

AU - Hespeels, Boris

AU - Heuskin, Anne Catherine

AU - Kronenberg, Jessica

AU - Milojevic, Tetyana

AU - Miranda, Silvana

AU - Moris, Victoria

AU - Penninckx, Sébastien

AU - Radstake, Wilhelmina E.

AU - Rehnberg, Emil

AU - Rettberg, Petra

AU - Tabury, Kevin

AU - Van Doninck, Karine

AU - Van Hoey, Olivier

AU - Vogin, Guillaume

AU - Socol, Yehoshua

PY - 2023/1/1

Y1 - 2023/1/1

N2 - The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

AB - The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field. After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure. The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

KW - Cancer risk

KW - Cataract

KW - Chromosomal aberrations

KW - Galactic cosmic rays (GCR)

KW - Light flashes

KW - Monte Carlo methods

KW - Particle accelerators

KW - Radiation belts

KW - Solar particle events (SPE)

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