TY - JOUR
T1 - Sparing of bone marrow stem cells by long-term administration of na-alginate to 226ra contaminated mice
AU - Schoeters, G. E.R.
AU - Van Puymbroeck, S.
AU - Colard, J.
AU - Vanderborght, O. L.J.
PY - 1979
Y1 - 1979
N2 - 226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against αirradiation from 226Ra contamination. Doses from 4 to 14 μCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed, but from 9·0 μCi/kg a decrease in the number of surviving stem cells is observable in non treated animals, while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226Ra dose which accounts for damage to marrow stem cells within the range of αrays at the endosteal surfaces.
AB - 226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against αirradiation from 226Ra contamination. Doses from 4 to 14 μCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed, but from 9·0 μCi/kg a decrease in the number of surviving stem cells is observable in non treated animals, while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226Ra dose which accounts for damage to marrow stem cells within the range of αrays at the endosteal surfaces.
UR - http://www.scopus.com/inward/record.url?scp=0018733683&partnerID=8YFLogxK
U2 - 10.1080/09553007914551161
DO - 10.1080/09553007914551161
M3 - Article
C2 - 317600
AN - SCOPUS:0018733683
SN - 0955-3002
VL - 36
SP - 379
EP - 386
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 4
ER -