Sparing of bone marrow stem cells by long-term administration of na-alginate to 226ra contaminated mice

G. E.R. Schoeters; S. Van Puymbroeck; J. Colard; O. L.J. Vanderborght

doi:10.1080/09553007914551161

Sparing of bone marrow stem cells by long-term administration of na-alginate to ²²⁶ra contaminated mice

G. E.R. Schoeters, S. Van Puymbroeck, J. Colard, O. L.J. Vanderborght

Research output › peer-review

Abstract

²²⁶Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against αirradiation from ²²⁶Ra contamination. Doses from 4 to 14 μCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed, but from 9·0 μCi/kg a decrease in the number of surviving stem cells is observable in non treated animals, while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of ²²⁶Ra mainly from the endosteal bone surfaces, reducing the local ²²⁶Ra dose which accounts for damage to marrow stem cells within the range of αrays at the endosteal surfaces.

Original language	English
Pages (from-to)	379-386
Number of pages	8
Journal	International Journal of Radiation Biology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1080/09553007914551161
State	Published - 1979

Funding

Acknowledgments We thank G . Gerber for the curve fitting . J . Duplan for a fruitful stay in his laboratory and L . Tessens for his inventive animal care . Part of this research was supported by EURATOM contract 233-77-1 BLOB .

Funders	Funder number
Horizon Europe	233-77-1 BLOB

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1080/09553007914551161

Cite this

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title = "Sparing of bone marrow stem cells by long-term administration of na-alginate to 226ra contaminated mice",

abstract = "226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against αirradiation from 226Ra contamination. Doses from 4 to 14 μCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed, but from 9·0 μCi/kg a decrease in the number of surviving stem cells is observable in non treated animals, while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226Ra dose which accounts for damage to marrow stem cells within the range of αrays at the endosteal surfaces.",

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N2 - 226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against αirradiation from 226Ra contamination. Doses from 4 to 14 μCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed, but from 9·0 μCi/kg a decrease in the number of surviving stem cells is observable in non treated animals, while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226Ra dose which accounts for damage to marrow stem cells within the range of αrays at the endosteal surfaces.

AB - 226Ra toxicity studies form the experimental basis for the estimation of radiation risk from internal emitters in man. We investigated whether treatment with Na-alginate is able to protect haemopoietic bone marrow cells against αirradiation from 226Ra contamination. Doses from 4 to 14 μCi/kg were injected intraperitoneally in mice 12 days before the start of the treatment. Damage to marrow stem cells was assessed by the exogene clonal spleen technique. Collection of marrow cells by two methods was compared. In the lower dose groups no influence on stem cell survival is noticed, but from 9·0 μCi/kg a decrease in the number of surviving stem cells is observable in non treated animals, while in animals treated with Na-alginate fewer stem cells are damaged. These preliminary data agree with the hypothesis that Na-alginate stimulates removal of 226Ra mainly from the endosteal bone surfaces, reducing the local 226Ra dose which accounts for damage to marrow stem cells within the range of αrays at the endosteal surfaces.

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