TY - JOUR
T1 - SPECT Imaging of Joint Inflammation with Nanobodies Targeting the Macrophage Mannose Receptor in a Mouse Model for Rheumatoid Arthritis
AU - Put, Stéphanie
AU - Schoonooghe, Steve
AU - Devoogdt, Nick
AU - Schurgers, Evelien
AU - Avau, Anneleen
AU - Mitera, Tania
AU - D'huyvetter, Matthias
AU - De Baetselier, Patrick
AU - Raes, Geert
AU - Lahoutte, Tony
AU - Matthys, Patrick
A2 - Baatout, Sarah
A2 - Aerts, An
A2 - Impens, Nathalie
N1 - Score = 10
PY - 2013/2/27
Y1 - 2013/2/27
N2 - Rheumatoid arthritis (RA) is a chronic autoimmune disease
occurring in approximately 1% of the worldwide population.
The disease primarily affects the joints, where inflammatory
cells, such as macrophages, invade the synovium and cause
cartilage and bone destruction. Currently, it is difficult to
efficiently diagnose and monitor early-stage RA. In this study,
we investigated whether SPECT/micro-CT imaging with 99mTclabeled
Nanobodies directed against the macrophage mannose
receptor (MMR) is a useful tool for monitoring and quantifying
joint inflammation in collagen-induced arthritis (CIA), a mouse
model for RA. The expression of MMR was analyzed on macrophages
and osteoclasts generated in vitro and in cells obtained
from various organs from mice with CIA.
AB - Rheumatoid arthritis (RA) is a chronic autoimmune disease
occurring in approximately 1% of the worldwide population.
The disease primarily affects the joints, where inflammatory
cells, such as macrophages, invade the synovium and cause
cartilage and bone destruction. Currently, it is difficult to
efficiently diagnose and monitor early-stage RA. In this study,
we investigated whether SPECT/micro-CT imaging with 99mTclabeled
Nanobodies directed against the macrophage mannose
receptor (MMR) is a useful tool for monitoring and quantifying
joint inflammation in collagen-induced arthritis (CIA), a mouse
model for RA. The expression of MMR was analyzed on macrophages
and osteoclasts generated in vitro and in cells obtained
from various organs from mice with CIA.
KW - Rheumatoid Arthritis
KW - Nanobody
KW - Mannose Receptor
KW - SPECT imaging
UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_128828
UR - http://knowledgecentre.sckcen.be/so2/bibref/10211
U2 - 10.2967/jnumed.112.111781
DO - 10.2967/jnumed.112.111781
M3 - Article
SN - 0161-5505
VL - 54
SP - 807
EP - 814
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 5
ER -