Stromal stem cells (CFU‐f) in yolk sac, liver, spleen and bone marrow of pre‐ and postnatal mice

Rosette L. Van Den Heuvel; Sigrid R.M. Versele; Greet E.R. Schoeters; Oscar L. Oscar

doi:10.1111/j.1365-2141.1987.tb06884.x

Stromal stem cells (CFU‐f) in yolk sac, liver, spleen and bone marrow of pre‐ and postnatal mice

Rosette L. Van Den Heuvel, Sigrid R.M. Versele, Greet E.R. Schoeters, Oscar L. Oscar

Research output › peer-review

Abstract

Our results demonstrate that in yolk sac, liver, spleen and femoral bone marrow of mice at ages ranging between 11 d of gestation and adult life, important changes in the stromal stem cell population (CFU‐f assay) occur which are correlated with haemopoiesis. (1) In the liver, spleen and bone marrow, high numbers of CFU‐f precede high haemo‐poietic stem cell values. (2) As haemopoiesis starts in the spleen. CFU‐f numbers in fetal liver are low. Similarly, CFU‐f numbers decrease in the spleen as bone marrow haemopoiesis starts. This suggests the existence of a migration stream of stromal stem cells. (3) In spleen and bone marrow, CFU‐f numbers decrease towards adult life as these organs maintain a stable haemopoietic activity.

Original language	English
Pages (from-to)	15-20
Number of pages	6
Journal	British Journal of Haematology
Volume	66
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2141.1987.tb06884.x
State	Published - May 1987

ASJC Scopus subject areas

Hematology

Access to Document

10.1111/j.1365-2141.1987.tb06884.x

Cite this

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title = "Stromal stem cells (CFU‐f) in yolk sac, liver, spleen and bone marrow of pre‐ and postnatal mice",

abstract = "Our results demonstrate that in yolk sac, liver, spleen and femoral bone marrow of mice at ages ranging between 11 d of gestation and adult life, important changes in the stromal stem cell population (CFU‐f assay) occur which are correlated with haemopoiesis. (1) In the liver, spleen and bone marrow, high numbers of CFU‐f precede high haemo‐poietic stem cell values. (2) As haemopoiesis starts in the spleen. CFU‐f numbers in fetal liver are low. Similarly, CFU‐f numbers decrease in the spleen as bone marrow haemopoiesis starts. This suggests the existence of a migration stream of stromal stem cells. (3) In spleen and bone marrow, CFU‐f numbers decrease towards adult life as these organs maintain a stable haemopoietic activity.",

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T1 - Stromal stem cells (CFU‐f) in yolk sac, liver, spleen and bone marrow of pre‐ and postnatal mice

AU - Van Den Heuvel, Rosette L.

AU - Versele, Sigrid R.M.

AU - Schoeters, Greet E.R.

AU - Oscar, Oscar L.

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N2 - Our results demonstrate that in yolk sac, liver, spleen and femoral bone marrow of mice at ages ranging between 11 d of gestation and adult life, important changes in the stromal stem cell population (CFU‐f assay) occur which are correlated with haemopoiesis. (1) In the liver, spleen and bone marrow, high numbers of CFU‐f precede high haemo‐poietic stem cell values. (2) As haemopoiesis starts in the spleen. CFU‐f numbers in fetal liver are low. Similarly, CFU‐f numbers decrease in the spleen as bone marrow haemopoiesis starts. This suggests the existence of a migration stream of stromal stem cells. (3) In spleen and bone marrow, CFU‐f numbers decrease towards adult life as these organs maintain a stable haemopoietic activity.

AB - Our results demonstrate that in yolk sac, liver, spleen and femoral bone marrow of mice at ages ranging between 11 d of gestation and adult life, important changes in the stromal stem cell population (CFU‐f assay) occur which are correlated with haemopoiesis. (1) In the liver, spleen and bone marrow, high numbers of CFU‐f precede high haemo‐poietic stem cell values. (2) As haemopoiesis starts in the spleen. CFU‐f numbers in fetal liver are low. Similarly, CFU‐f numbers decrease in the spleen as bone marrow haemopoiesis starts. This suggests the existence of a migration stream of stromal stem cells. (3) In spleen and bone marrow, CFU‐f numbers decrease towards adult life as these organs maintain a stable haemopoietic activity.

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