Studies on detoxication by the perfused liver: II. Bilirubin conjugation and excretion after irradiation

G. B. Gerber; J. Remy-Defraigne

doi:10.1080/09553006314550851

Studies on detoxication by the perfused liver: II. Bilirubin conjugation and excretion after irradiation

G. B. Gerber, J. Remy-Defraigne

Research output › peer-review

Abstract

Formation of conjugated bilirubin and its excretion into the bile has been studied in the isolated perfused liver of normal and x-irradiated rats. Bilirubin is removed rapidly from the blood and is excreted, after a lag-period, to about 70-85 per cent as conjugated bilirubin into the bile. Conjugation occurs mainly with glucuronic acid but also with other compounds. Removal of bilirubin from the blood and excretion of conjugated bilirubin in the bile are delayed in the perfused liver of x-irradiated rats.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	International Journal of Radiation Biology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1080/09553006314550851
State	Published - 1963
Externally published	Yes

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1080/09553006314550851

Cite this

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abstract = "Formation of conjugated bilirubin and its excretion into the bile has been studied in the isolated perfused liver of normal and x-irradiated rats. Bilirubin is removed rapidly from the blood and is excreted, after a lag-period, to about 70-85 per cent as conjugated bilirubin into the bile. Conjugation occurs mainly with glucuronic acid but also with other compounds. Removal of bilirubin from the blood and excretion of conjugated bilirubin in the bile are delayed in the perfused liver of x-irradiated rats.",

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