225Ac/213Bi radionuclide generators for the separation of 213Bi towards clinical demands

Hongshan Zhu; Stephan Heinitz; Koen Binnemans; Steven Mullens; Thomas Cardinaels

doi:10.1039/d4qi00326h

²²⁵Ac/²¹³Bi radionuclide generators for the separation of ²¹³Bi towards clinical demands

Hongshan Zhu, Stephan Heinitz, Koen Binnemans, Steven Mullens, Thomas Cardinaels

Research output › peer-review

Abstract

Bismuth-213 (²¹³Bi) is a promising radionuclide for clinical application in targeted alpha therapy of cancers. ²²⁵Ac/²¹³Bi radionuclide generators are of particular interest for the production/separation of ²¹³Bi. This review aims to give an overview of the current status of ²²⁵Ac production, ²²⁵Ac/²¹³Bi radionuclide generator systems, the types of adsorbents, separation conditions, separation mechanisms, and critical challenges. The review also provides guidance for investigating emerging new sorbents that can be developed to overcome the limitations of currently used sorbents.

Original language	English
Pages (from-to)	4499-4527
Number of pages	29
Journal	Inorganic Chemistry Frontiers
Volume	11
Issue number	15
DOIs	https://doi.org/10.1039/d4qi00326h
State	Published - 10 Jun 2024

ASJC Scopus subject areas

Inorganic Chemistry

Access to Document

10.1039/d4qi00326h

Cite this

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title = "225Ac/213Bi radionuclide generators for the separation of 213Bi towards clinical demands",

abstract = "Bismuth-213 (213Bi) is a promising radionuclide for clinical application in targeted alpha therapy of cancers. 225Ac/213Bi radionuclide generators are of particular interest for the production/separation of 213Bi. This review aims to give an overview of the current status of 225Ac production, 225Ac/213Bi radionuclide generator systems, the types of adsorbents, separation conditions, separation mechanisms, and critical challenges. The review also provides guidance for investigating emerging new sorbents that can be developed to overcome the limitations of currently used sorbents.",

keywords = "Clinical application, Radioisotopes, Critical challenges, Generator systems, Radionuclide generators, Separation",

author = "Hongshan Zhu and Stephan Heinitz and Koen Binnemans and Steven Mullens and Thomas Cardinaels",

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T1 - 225Ac/213Bi radionuclide generators for the separation of 213Bi towards clinical demands

AU - Zhu, Hongshan

AU - Heinitz, Stephan

AU - Binnemans, Koen

AU - Mullens, Steven

AU - Cardinaels, Thomas

PY - 2024/6/10

Y1 - 2024/6/10

N2 - Bismuth-213 (213Bi) is a promising radionuclide for clinical application in targeted alpha therapy of cancers. 225Ac/213Bi radionuclide generators are of particular interest for the production/separation of 213Bi. This review aims to give an overview of the current status of 225Ac production, 225Ac/213Bi radionuclide generator systems, the types of adsorbents, separation conditions, separation mechanisms, and critical challenges. The review also provides guidance for investigating emerging new sorbents that can be developed to overcome the limitations of currently used sorbents.

AB - Bismuth-213 (213Bi) is a promising radionuclide for clinical application in targeted alpha therapy of cancers. 225Ac/213Bi radionuclide generators are of particular interest for the production/separation of 213Bi. This review aims to give an overview of the current status of 225Ac production, 225Ac/213Bi radionuclide generator systems, the types of adsorbents, separation conditions, separation mechanisms, and critical challenges. The review also provides guidance for investigating emerging new sorbents that can be developed to overcome the limitations of currently used sorbents.

KW - Clinical application

KW - Radioisotopes

KW - Critical challenges

KW - Generator systems

KW - Radionuclide generators

KW - Separation

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