Synthesis of NAD and catabolism of nicotinic acid in the isolated perfused liver of normal and x-irradiated rat

G. B. Gerber; B. Zicha; J. Deroo

doi:10.1080/09553006914550711

Synthesis of NAD and catabolism of nicotinic acid in the isolated perfused liver of normal and x-irradiated rat

G. B. Gerber, B. Zicha, J. Deroo

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Abstract

The synthesis of NAD and the formation of catabolites from nicotinic acid ¹⁴C was studied in isolated perfused liver from normal and x-irradiated rats. Large amounts of nicotinic acid and nicotinamide increase NAD content of perfused liver as they do in vivo. Synthesis of NAD is slightly diminished after irradiation, particularly under loading conditions whereas its catabolism is enhanced. Data for the rates of reactions are given for different pathways involved in NAD metabolism.

Original language	English
Pages (from-to)	425-434
Number of pages	10
Journal	International Journal of Radiation Biology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1080/09553006914550711
State	Published - 1969

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1080/09553006914550711

Cite this

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title = "Synthesis of NAD and catabolism of nicotinic acid in the isolated perfused liver of normal and x-irradiated rat",

abstract = "The synthesis of NAD and the formation of catabolites from nicotinic acid 14C was studied in isolated perfused liver from normal and x-irradiated rats. Large amounts of nicotinic acid and nicotinamide increase NAD content of perfused liver as they do in vivo. Synthesis of NAD is slightly diminished after irradiation, particularly under loading conditions whereas its catabolism is enhanced. Data for the rates of reactions are given for different pathways involved in NAD metabolism.",

author = "Gerber, {G. B.} and B. Zicha and J. Deroo",

year = "1969",

doi = "10.1080/09553006914550711",

language = "English",

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journal = "International Journal of Radiation Biology",

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publisher = "Taylor & Francis (CRC)",

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AU - Gerber, G. B.

AU - Zicha, B.

AU - Deroo, J.

PY - 1969

Y1 - 1969

N2 - The synthesis of NAD and the formation of catabolites from nicotinic acid 14C was studied in isolated perfused liver from normal and x-irradiated rats. Large amounts of nicotinic acid and nicotinamide increase NAD content of perfused liver as they do in vivo. Synthesis of NAD is slightly diminished after irradiation, particularly under loading conditions whereas its catabolism is enhanced. Data for the rates of reactions are given for different pathways involved in NAD metabolism.

AB - The synthesis of NAD and the formation of catabolites from nicotinic acid 14C was studied in isolated perfused liver from normal and x-irradiated rats. Large amounts of nicotinic acid and nicotinamide increase NAD content of perfused liver as they do in vivo. Synthesis of NAD is slightly diminished after irradiation, particularly under loading conditions whereas its catabolism is enhanced. Data for the rates of reactions are given for different pathways involved in NAD metabolism.

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JO - International Journal of Radiation Biology

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