Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody

Matthias D'huyvetter; Cécile Vincke; Catarina Xavier; An Aerts; Nathalie Impens; Sarah Baatout; Hendrik De Raeve; Serge Muyldermans; Vicky Caveliers; Nick Devoogdt; Tony Lahoutte

doi:10.7150/thno.8156

Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody

Matthias D'huyvetter
, Cécile Vincke
, Catarina Xavier
, An Aerts
, Nathalie Impens
, Sarah Baatout
, Hendrik De Raeve
, Serge Muyldermans
, Vicky Caveliers
, Nick Devoogdt
, Tony Lahoutte

Research output › peer-review

Abstract

RIT (Radioimmunotherapy) has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW

Original language	English
Pages (from-to)	708-720
Journal	Theranostics
Volume	4
Issue number	7
DOIs	https://doi.org/10.7150/thno.8156
State	Published - Apr 2014

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10.7150/thno.8156License: Other

Cite this

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abstract = "RIT (Radioimmunotherapy) has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW",

keywords = "HER2, nanobody, targeted radionuclide therapy, 177-Lutetium",

author = "Matthias D'huyvetter and C{\'e}cile Vincke and Catarina Xavier and An Aerts and Nathalie Impens and Sarah Baatout and \{De Raeve\}, Hendrik and Serge Muyldermans and Vicky Caveliers and Nick Devoogdt and Tony Lahoutte",

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T1 - Targeted Radionuclide Therapy with A 177Lu-labeled Anti-HER2 Nanobody

AU - D'huyvetter, Matthias

AU - Vincke, Cécile

AU - Xavier, Catarina

AU - Aerts, An

AU - Impens, Nathalie

AU - Baatout, Sarah

AU - De Raeve, Hendrik

AU - Muyldermans, Serge

AU - Caveliers, Vicky

AU - Devoogdt, Nick

AU - Lahoutte, Tony

N1 - Score = 10

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N2 - RIT (Radioimmunotherapy) has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW

AB - RIT (Radioimmunotherapy) has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MW

KW - HER2

KW - nanobody

KW - targeted radionuclide therapy

KW - 177-Lutetium

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_134992

UR - http://knowledgecentre.sckcen.be/so2/bibref/11432

U2 - 10.7150/thno.8156

DO - 10.7150/thno.8156

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IS - 7

ER -