TERF1 and TERF2 downregulate telomere length in cognitive deficit at the late period after low-dose exposure.

Dimitry Bazyka; Elina Ilyenko; KN Loganovsky; Rafi Benotmane; SA Chumak; Nathalie Impens

TERF1 and TERF2 downregulate telomere length in cognitive deficit at the late period after low-dose exposure.

Dimitry Bazyka, Elina Ilyenko, KN Loganovsky, Rafi Benotmane, SA Chumak, Nathalie Impens

Research output › peer-review

Abstract

Purpose - to explore the role of radiation dose on gene regulation of telomere length and its influence on the patho-genesis of cerebrovascular neurocognitive deficit at the remote period of low-dose irradiation as a result of the Chornobyl accident. Materials and methods. We performed a study of TERF1, TERF2 and TERT genes expression (GE) by RT-PCR, and relative telomere length (RTL) by flow-FISH in 258 clean-up workers of Chornobyl accident divided by radiation dose groups (range 22-2800 mSv) and 78 controls with vascular cognitive deficit.

Original language	English
Pages (from-to)	170-185
Journal	Problems of radiation medicine and radiobiology
Volume	19
Issue number	09
State	Published - Sep 2014

Cite this

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title = "TERF1 and TERF2 downregulate telomere length in cognitive deficit at the late period after low-dose exposure.",

abstract = "Purpose - to explore the role of radiation dose on gene regulation of telomere length and its influence on the patho-genesis of cerebrovascular neurocognitive deficit at the remote period of low-dose irradiation as a result of the Chornobyl accident. Materials and methods. We performed a study of TERF1, TERF2 and TERT genes expression (GE) by RT-PCR, and relative telomere length (RTL) by flow-FISH in 258 clean-up workers of Chornobyl accident divided by radiation dose groups (range 22-2800 mSv) and 78 controls with vascular cognitive deficit.",

keywords = "Chornobyl, TERF1, TERF2, TERT, cognitive deficit, gene expression, low-dose radiation, telomeres",

author = "Dimitry Bazyka and Elina Ilyenko and KN Loganovsky and Rafi Benotmane and SA Chumak and Nathalie Impens",

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year = "2014",

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TY - JOUR

T1 - TERF1 and TERF2 downregulate telomere length in cognitive deficit at the late period after low-dose exposure.

AU - Bazyka, Dimitry

AU - Ilyenko, Elina

AU - Loganovsky, KN

AU - Benotmane, Rafi

AU - Chumak, SA

A2 - Impens, Nathalie

N1 - Score = 10

PY - 2014/9

Y1 - 2014/9

N2 - Purpose - to explore the role of radiation dose on gene regulation of telomere length and its influence on the patho-genesis of cerebrovascular neurocognitive deficit at the remote period of low-dose irradiation as a result of the Chornobyl accident. Materials and methods. We performed a study of TERF1, TERF2 and TERT genes expression (GE) by RT-PCR, and relative telomere length (RTL) by flow-FISH in 258 clean-up workers of Chornobyl accident divided by radiation dose groups (range 22-2800 mSv) and 78 controls with vascular cognitive deficit.

AB - Purpose - to explore the role of radiation dose on gene regulation of telomere length and its influence on the patho-genesis of cerebrovascular neurocognitive deficit at the remote period of low-dose irradiation as a result of the Chornobyl accident. Materials and methods. We performed a study of TERF1, TERF2 and TERT genes expression (GE) by RT-PCR, and relative telomere length (RTL) by flow-FISH in 258 clean-up workers of Chornobyl accident divided by radiation dose groups (range 22-2800 mSv) and 78 controls with vascular cognitive deficit.

KW - Chornobyl

KW - TERF1

KW - TERF2

KW - TERT

KW - cognitive deficit

KW - gene expression

KW - low-dose radiation

KW - telomeres

UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_137818

UR - http://knowledgecentre.sckcen.be/so2/bibref/12104

M3 - Article

SN - 2304-8336

VL - 19

SP - 170

EP - 185

JO - Problems of radiation medicine and radiobiology

JF - Problems of radiation medicine and radiobiology

IS - 09

ER -