Closing the nuclear fuel cycle and transmuting Minor Actinides (MAs) can be considered as an application of the duty of care principle which says that, “before the final disposal of any waste, any possible chemical and/or physical treatment has to be applied in order to reduce the waste’s toxicity, provided the treatment does not convey unacceptable risks or unacceptable costs”. Forty years of complex research and development has shown that Accelerator Driven Systems could provide a solution to the challenge posed by spent nuclear fuels, by enabling the ability to considerably decrease their radiotoxicity lifetime burden and volume. In particular, a multilateral strategy of treatment of the MAs could be a commendable solution for both the countries phasing out the exploitation of nuclear energy and for those pursuing and developing this exploitation. The pre-industrial assessment of the technical and financial feasibility for industrialization is the next step. This applies to the four R&D and Demonstration building blocks: advanced separation, MAs’ loaded fuel fabrication, dedicated transmuters demonstration (MYRRHA) and provision for MAs’ fuel loaded processing. A global vision of the process leading to a sustainable option is proposed.