The importance of cytoskeleton proteins in megakaryocyte spreading and platelet formation

    Research outputpeer-review

    Abstract

    The release of platelets into the circulation is preceded by considerable morphologic change of the parent megakaryocyte. The cell extends cytoplasmic processes into the venous sinusoids, which develop constrictions at intervals, revealing putative platelets. The pattern of cytoskeletal distribution changes during the spreading of megakaryocytes in vitro. In this review, an attempt was made to summarize the data of the literature concerning the changes in the cytoskeletal pattern of megakaryocytes during their spreading and platelet formation.

    Original languageEnglish
    Pages (from-to)17-19
    Number of pages3
    JournalBlood reviews
    Volume10
    Issue number1
    DOIs
    StatePublished - 1996

    Funding

    This work was supported by a grant from the Fonds National de la Recherche Scientifique-T&vie (Grant no 7.4549.93). The author would like to thank Professor M. Symann, Dr C. Chatelain and Mr B. Chatelain for their continued support.

    FundersFunder number
    Not added7.4549.93

      ASJC Scopus subject areas

      • Hematology
      • Oncology

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