Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors

Paolo Colautti; Anna Bianchi; Anna Selva; Davide Bortot; Davide Mazzucconi; Andrea Pola; Stefano Agosteo; Giada Petringa; Pablo G.A. Cirrone; Valeria Conte

doi:10.1016/j.radmeas.2020.106386

Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors

Paolo Colautti, Anna Bianchi, Anna Selva, Davide Bortot, Davide Mazzucconi, Andrea Pola, Stefano Agosteo, Giada Petringa, Pablo G.A. Cirrone, Valeria Conte

Research output › peer-review

Abstract

A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). Measurements were taken at the same different positions in a PMMA phantom, in order to analyse the detector response differences. Finally, a weighting function was applied to the spectra to see if the microdosimetric detectors are able to monitor RBE data for glioma cells (U87) irradiated at six positions along the same modulated 62-MeV proton beam. The results obtained with the three microdosimeters are compared and discussed.

Original language	English
Article number	106386
Pages (from-to)	1-5
Number of pages	5
Journal	Radiation Measurements
Volume	136
DOIs	https://doi.org/10.1016/j.radmeas.2020.106386
State	Published - 3 Jun 2020

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Cite this

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title = "Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors",

abstract = "A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). Measurements were taken at the same different positions in a PMMA phantom, in order to analyse the detector response differences. Finally, a weighting function was applied to the spectra to see if the microdosimetric detectors are able to monitor RBE data for glioma cells (U87) irradiated at six positions along the same modulated 62-MeV proton beam. The results obtained with the three microdosimeters are compared and discussed.",

keywords = "Microdosimetry, Proton therapy, Proton RBE, Mini-TEPC, Silicon telescope detector, MicroPlus Bridge detector",

author = "Paolo Colautti and Anna Bianchi and Anna Selva and Davide Bortot and Davide Mazzucconi and Andrea Pola and Stefano Agosteo and Giada Petringa and Cirrone, {Pablo G.A.} and Valeria Conte",

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T1 - Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors

AU - Colautti, Paolo

AU - Bianchi, Anna

AU - Selva, Anna

AU - Bortot, Davide

AU - Mazzucconi, Davide

AU - Pola, Andrea

AU - Agosteo, Stefano

AU - Petringa, Giada

AU - Cirrone, Pablo G.A.

AU - Conte, Valeria

N1 - Score=10

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N2 - A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). Measurements were taken at the same different positions in a PMMA phantom, in order to analyse the detector response differences. Finally, a weighting function was applied to the spectra to see if the microdosimetric detectors are able to monitor RBE data for glioma cells (U87) irradiated at six positions along the same modulated 62-MeV proton beam. The results obtained with the three microdosimeters are compared and discussed.

AB - A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). Measurements were taken at the same different positions in a PMMA phantom, in order to analyse the detector response differences. Finally, a weighting function was applied to the spectra to see if the microdosimetric detectors are able to monitor RBE data for glioma cells (U87) irradiated at six positions along the same modulated 62-MeV proton beam. The results obtained with the three microdosimeters are compared and discussed.

KW - Microdosimetry

KW - Proton therapy

KW - Proton RBE

KW - Mini-TEPC

KW - Silicon telescope detector

KW - MicroPlus Bridge detector

UR - https://ecm.sckcen.be/OTCS/llisapi.dll/open/40245310

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JF - Radiation Measurements

M1 - 106386

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