Translocations in mouse spermatogonia after exposure to unequally fractionated doses of X-rays

P. P.W. Van Buul; A. Léonard

doi:10.1016/0027-5107(74)90064-5

Translocations in mouse spermatogonia after exposure to unequally fractionated doses of X-rays

P. P.W. Van Buul, A. Léonard

Research output › peer-review

Abstract

The influence of various X-ray fractionation regimes on translocation induction in mouse spermatogonia was studied. Splitting a single exposure of 600 R into two fractions of 300 R separated by 24 h did not influence the translocation yield (7.58% vs. 8.35%). When the dose was given in the unequal fractions,100 R+500 R and 500 R+100 R, with the same 24 h between the fractions, the translocation frequency was significantly altered (10,19 and 4.94%, respectively). As a possible explanation of these findings it is assumed that the relatively resistant cells surviving the first fraction of the dose are sensitized towards translocation induction when receiving the second fraction of the dose.

Original language	English
Pages (from-to)	361-365
Number of pages	5
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/0027-5107(74)90064-5
State	Published - Dec 1974

Funding

The work was supported by the international Atomic Energy Agency contract No. I349/RL/RB, the Association between Euratom and the University of Leiden, contract No. o52-64-I-BIAN, the J. A. Cohen Institute for Radiopathology and Radiation Protection, by Research Contract Ematom/C.E.N. o95 72-I-BIO B, and by grants from the "Fonds de la Recherche Scientifique l%ndamentale Collective".

Funders	Funder number
CNRS - Centre National de la Recherche Scientifique
International Atomic Energy Agency (IAEA)

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

Access to Document

10.1016/0027-5107(74)90064-5

Cite this

@article{48fcd56e5a1547dba6bc1693acec535b,

title = "Translocations in mouse spermatogonia after exposure to unequally fractionated doses of X-rays",

abstract = "The influence of various X-ray fractionation regimes on translocation induction in mouse spermatogonia was studied. Splitting a single exposure of 600 R into two fractions of 300 R separated by 24 h did not influence the translocation yield (7.58% vs. 8.35%). When the dose was given in the unequal fractions,100 R+500 R and 500 R+100 R, with the same 24 h between the fractions, the translocation frequency was significantly altered (10,19 and 4.94%, respectively). As a possible explanation of these findings it is assumed that the relatively resistant cells surviving the first fraction of the dose are sensitized towards translocation induction when receiving the second fraction of the dose.",

author = "{Van Buul}, {P. P.W.} and A. L{\'e}onard",

year = "1974",

month = dec,

doi = "10.1016/0027-5107(74)90064-5",

language = "English",

volume = "25",

pages = "361--365",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

issn = "0027-5107",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Translocations in mouse spermatogonia after exposure to unequally fractionated doses of X-rays

AU - Van Buul, P. P.W.

AU - Léonard, A.

PY - 1974/12

Y1 - 1974/12

N2 - The influence of various X-ray fractionation regimes on translocation induction in mouse spermatogonia was studied. Splitting a single exposure of 600 R into two fractions of 300 R separated by 24 h did not influence the translocation yield (7.58% vs. 8.35%). When the dose was given in the unequal fractions,100 R+500 R and 500 R+100 R, with the same 24 h between the fractions, the translocation frequency was significantly altered (10,19 and 4.94%, respectively). As a possible explanation of these findings it is assumed that the relatively resistant cells surviving the first fraction of the dose are sensitized towards translocation induction when receiving the second fraction of the dose.

AB - The influence of various X-ray fractionation regimes on translocation induction in mouse spermatogonia was studied. Splitting a single exposure of 600 R into two fractions of 300 R separated by 24 h did not influence the translocation yield (7.58% vs. 8.35%). When the dose was given in the unequal fractions,100 R+500 R and 500 R+100 R, with the same 24 h between the fractions, the translocation frequency was significantly altered (10,19 and 4.94%, respectively). As a possible explanation of these findings it is assumed that the relatively resistant cells surviving the first fraction of the dose are sensitized towards translocation induction when receiving the second fraction of the dose.

UR - http://www.scopus.com/inward/record.url?scp=0016272782&partnerID=8YFLogxK

U2 - 10.1016/0027-5107(74)90064-5

DO - 10.1016/0027-5107(74)90064-5

M3 - Article

C2 - 4437574

AN - SCOPUS:0016272782

SN - 0027-5107

VL - 25

SP - 361

EP - 365

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 3

ER -