TY - JOUR
T1 - Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain.
AU - Verheyde, Joris
AU - Benotmane, Rafi
A2 - de Saint-Georges, Louis
A2 - Jacquet, Paul
N1 - Score=10
PY - 2006/12/21
Y1 - 2006/12/21
N2 - Prenatal radiation exposure may have serious consequences for normal brain development. Results of epidemiological studies clearly pointed towards an increased risk of mental retardation in children of the surviving women of the Hiroshima/Nagasaki atomic bombing when in utero exposure had occurred between weeks 8 and 15 of pregnancy or, at a lower extend between weeks 15 and 25. The high sensitivity of the developing brain, in comparison to the adult brain is related to its higher number of non-differentiated, dividing neural precursor cells. Exposure of the developing brain to ionizing radiation can lead to three main outcomes in the developing brain, depending on the radiation dose and the elapsed period after irradiation. A first event occurs early after irradiation and triggers disturbances in cell proliferation, migration, differentiation, and cell death. A second event involves the generation of morphological abnormalities in the developing brain, if the radiation dose is sufficient. A third event involves cognitive dysfunctions that are a direct consequence from a disturbance in regional brain formation. The latter results from exposure to low doses and is usually only observed in the later period of development. In order to understand the mechanisms of radiation-induced cognitive dysfunctions.
AB - Prenatal radiation exposure may have serious consequences for normal brain development. Results of epidemiological studies clearly pointed towards an increased risk of mental retardation in children of the surviving women of the Hiroshima/Nagasaki atomic bombing when in utero exposure had occurred between weeks 8 and 15 of pregnancy or, at a lower extend between weeks 15 and 25. The high sensitivity of the developing brain, in comparison to the adult brain is related to its higher number of non-differentiated, dividing neural precursor cells. Exposure of the developing brain to ionizing radiation can lead to three main outcomes in the developing brain, depending on the radiation dose and the elapsed period after irradiation. A first event occurs early after irradiation and triggers disturbances in cell proliferation, migration, differentiation, and cell death. A second event involves the generation of morphological abnormalities in the developing brain, if the radiation dose is sufficient. A third event involves cognitive dysfunctions that are a direct consequence from a disturbance in regional brain formation. The latter results from exposure to low doses and is usually only observed in the later period of development. In order to understand the mechanisms of radiation-induced cognitive dysfunctions.
KW - ionizing radiation
KW - developing brain
KW - intracellular signalingpathways
KW - cognitive defects
UR - http://ecm.sckcen.be/OTCS/llisapi.dll/open/ezp_76059
UR - http://knowledgecentre.sckcen.be/so2/bibref/3938
U2 - 10.1016/j.brainresrev.2006.09.004
DO - 10.1016/j.brainresrev.2006.09.004
M3 - Article
VL - 53
SP - 312
EP - 320
JO - Brain research reviews
JF - Brain research reviews
IS - 2
ER -