VIP-helodermin receptors in the murine virus-induced t lymphoma cell line BL/VL3 recover less rapidly than βadrenoceptors after down regulation

C. Damien, P. Robberecht, J. Abello, R. Hooghe, J. Christophe

    Research output › peer-review

    Abstract

    The time course of recovery of βadrenergic and VIP/helodermin receptors after homologous and heterologous down regulation was studied in the murine lymphoma cell line BL/VL3, a neoplastic equivalent of immature T cells. The heterologous part of isoproterenol down regulation was rapidly reversed, even in the presence of cycloheximide, suggesting that down regulation was linked to ligand-receptor interaction and/or cyclic AMP increase. Homologous down regulations of βadrenoceptors and VIP/helodermin receptors were less rapidly reversible and depended on protein synthesis as they were inhibited by cycloheximide: βadrenoceptors recovered faster than VIP/helodermin receptors.

    Original languageEnglish
    Pages (from-to)441-449
    Number of pages9
    JournalJournal of Receptors and Signal Transduction
    Volume9
    Issue number6
    DOIs
    StatePublished - 1989

    Funding

    Aided by grant 3.4571.85 from the Fonds de la Recherche Scientifique Maicale (Belgium) and grant STJ-0001-1-B from the Comnission des Comnunautes EuroMennes (E.E.C.) and a grant from the Bekales Foundation (Liechtenstein).

    FundersFunder number
    Not addedSTJ-0001-1-B

      ASJC Scopus subject areas

      • Biochemistry
      • Molecular Biology
      • Cell Biology

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